Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University, 310016, Hangzhou, China.
School of Medicine, Zhejiang University, 310058, Hangzhou, China.
Nat Commun. 2023 Sep 14;14(1):5699. doi: 10.1038/s41467-023-41389-1.
Phototherapy of deep tumors still suffers from many obstacles, such as limited near-infrared (NIR) tissue penetration depth and low accumulation efficiency within the target sites. Herein, stimuli-sensitive tumor-targeted photodynamic nanoparticles (STPNs) with persistent luminescence for the treatment of deep tumors are reported. Purpurin 18 (Pu18), a porphyrin derivative, is utilized as a photosensitizer to produce persistent luminescence in STPNs, while lanthanide-doped upconversion nanoparticles (UCNPs) exhibit bioimaging properties and possess high photostability that can enhance photosensitizer efficacy. STPNs are initially stimulated by NIR irradiation before intravenous administration and accumulate at the tumor site to enter the cells through the HER2 receptor. Due to Pu18 afterglow luminescence properties, STPNs can continuously generate ROS to inhibit NFκB nuclear translocation, leading to tumor cell apoptosis. Moreover, STPNs can be used for diagnostic purposes through MRI and intraoperative NIR navigation. STPNs exceptional antitumor properties combined the advantages of UCNPs and persistent luminescence, representing a promising phototherapeutic strategy for deep tumors.
深肿瘤的光疗仍然存在许多障碍，例如近红外（NIR）组织穿透深度有限，以及在目标部位的积累效率低。在此，报道了一种具有持续发光的用于治疗深肿瘤的刺激响应型肿瘤靶向光动力纳米颗粒（STPN）。卟啉衍生物紫红素 18（Pu18）被用作光敏剂以在 STPN 中产生持续发光，而镧系掺杂上转换纳米颗粒（UCNP）则具有生物成像特性和高的光稳定性，可增强光敏剂的功效。STPN 首先在静脉给药前通过 NIR 照射进行刺激，并在肿瘤部位聚集，通过 HER2 受体进入细胞。由于 Pu18 的余晖发光特性，STPN 可以持续产生 ROS 来抑制 NFκB 核易位，导致肿瘤细胞凋亡。此外，STPN 可以通过 MRI 和术中 NIR 导航进行诊断。STPN 优异的抗肿瘤特性结合了 UCNP 和持续发光的优点，为深肿瘤的光疗提供了一种有前途的策略。
