Department of Abdominal Oncology, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
Department of Interventional Oncology, Hospital of Chengdu University of Traditional Chinese Medicine University, Chengdu, People's Republic of China.
World J Surg. 2023 Dec;47(12):3192-3202. doi: 10.1007/s00268-023-07106-1. Epub 2023 Sep 14.
This study aims to compare the survival outcomes of metaplastic breast cancer (MPBC) with triple-negative breast cancer (TNBC) and identify prognostic factors that influence the survival outcomes of MPBC patients and TNBC patients.
Patients with nonmetastatic MPBC or TNBC were reviewed from our database. Patients' clinicopathologic and molecular features were analyzed with respect to outcomes, including disease-free survival (DFS) and overall survival (OS). Propensity score matching (PSM) with a one-to-three matching between MPBC patients and TNBC patients was performed.
A total of 857 female patients (76 MPBC patients and 781 TNBC patients) were included in this study. A subgroup of triple-negative MPBC (n = 60) was matched with TNBC (n = 180) cases based on patient characteristics and treatments. Kaplan-Meier analysis indicated that the MPBC group was associated with worse OS and DFS before (P = 0.0046 both) and after (P = 0.011 and P = 0.0046, respectively) PSM. Multivariable analysis revealed that a higher T stage (T > 2) (P = 0.032) and higher lymph node stage (N3 vs. N0-2, P = 0.012) were associated with worse OS after PSM. For DFS, the MPBC group (P = 0.012), higher T stage (T > 2) (P = 0.032), and higher lymph node stage (N3 vs. N0-2, P = 0.045) were associated with worse DFS. Among the 76 MPBC patients, a higher T stage and mesenchymal differentiation were associated with worse OS (pT1/2 vs. pT3/4 and mesenchymal differentiation vs. other subtypes, P = 0.007 and P = 0.011, respectively).
Compared with TNBC, MPBC was associated with worse OS and DFS. Mesenchymal differentiation has a worse DFS than other subtypes of MPBC.
本研究旨在比较间变性乳腺癌（MPBC）与三阴性乳腺癌（TNBC）的生存结局，并确定影响 MPBC 患者和 TNBC 患者生存结局的预后因素。
从我们的数据库中回顾了患有非转移性 MPBC 或 TNBC 的患者。分析了患者的临床病理和分子特征，以及结局，包括无病生存（DFS）和总生存（OS）。对 MPBC 患者和 TNBC 患者进行了倾向评分匹配（PSM），匹配比例为 1:3。
本研究共纳入 857 名女性患者（76 名 MPBC 患者和 781 名 TNBC 患者）。根据患者特征和治疗情况，将一组三阴性 MPBC（n=60）与 TNBC（n=180）病例进行了匹配。Kaplan-Meier 分析表明，在 PSM 之前（P=0.0046 均）和之后（P=0.011 和 P=0.0046，分别），MPBC 组的 OS 和 DFS 更差。多变量分析显示，较高的 T 分期（T>2）（P=0.032）和较高的淋巴结分期（N3 与 N0-2，P=0.012）与 PSM 后 OS 更差相关。对于 DFS，MPBC 组（P=0.012）、较高的 T 分期（T>2）（P=0.032）和较高的淋巴结分期（N3 与 N0-2，P=0.045）与 DFS 更差相关。在 76 名 MPBC 患者中，较高的 T 分期和间充质分化与 OS 更差相关（pT1/2 与 pT3/4 和间充质分化与其他亚型，P=0.007 和 P=0.011）。
与 TNBC 相比，MPBC 与 OS 和 DFS 更差相关。间充质分化的 MPBC 比其他亚型的 MPBC 具有更差的 DFS。
