Clinical Laboratory Sciences Program, School of Health Profession, Stony Brook University, Stony Brook, NY, USA.
Department of Neuroscience and Behavior, Stony Brook University, Stony Brook, NY, USA.
BMC Infect Dis. 2023 Sep 14;23(1):601. doi: 10.1186/s12879-023-08593-2.
Mycoplasma hominis is a facultative anaerobic bacterium commonly present in the urogenital tract. In recent years, M. hominis has increasingly been associated with extra-urogenital tract infections, particularly in immunosuppressed patients. Detecting M. hominis in a diagnostic laboratory can be challenging due to its slow growth rate, absence of a cell wall, and the requirements of specialized media and conditions for optimal growth. Consequently, it is necessary to establish guidelines for the detection of this microorganism and to request the appropriate microbiological work-up of immunosuppressed patients.
We hereby present two cases of solid organ transplant patients who developed M. hominis infection. Microscopic examination of the bronchial lavage and pleural fluid showed no microorganisms. However, upon inoculating the specimens onto routine microbiology media, the organism was successfully identified and confirmation was performed using 16S rDNA sequencing. Both patients received appropriate treatment resulting in the resolution of M. hominis infection.
The prompt detection of M. hominis in a clinical specimen can have a significant impact on patient care by allowing for early intervention and ultimately resulting in more favorable clinical outcomes, especially in transplant patients.
人型支原体是一种兼性厌氧细菌，通常存在于泌尿生殖道中。近年来，人型支原体与泌尿生殖道外感染的关系越来越密切，特别是在免疫抑制患者中。由于其生长缓慢、缺乏细胞壁以及对最佳生长所需的特殊培养基和条件的要求，在诊断实验室中检测人型支原体具有一定挑战性。因此，有必要制定该微生物的检测指南，并要求对免疫抑制患者进行适当的微生物学检查。
我们在此介绍两例实体器官移植患者发生人型支原体感染的病例。支气管灌洗液和胸腔液的显微镜检查未发现微生物。然而，将标本接种于常规微生物学培养基上后，成功鉴定出该病原体，并通过 16S rDNA 测序进行了确认。两名患者均接受了适当的治疗，人型支原体感染得到了治愈。
及时在临床标本中检测出人型支原体，可通过早期干预对患者的治疗产生重大影响，最终获得更有利的临床结果，尤其是在移植患者中。
