Dolan Mackenzie A, Elliott Zachary S, Arnold Christopher J
Department of Pharmacy, University of Virginia Health, P.O. Box 800674, Charlottesville, VA, 22908, USA.
Division of Infectious Diseases and International Health, University of Virginia School of Medicine, University of Virginia Health, P.O. Box 800419, Charlottesville, VA, USA.
IDCases. 2021 Jun 12;25:e01190. doi: 10.1016/j.idcr.2021.e01190. eCollection 2021.
species, specifically (), are commonly associated with genitourinary (GU) tract infectious syndromes. However, spp. can also be involved in extragenital infections, primarily in immunosuppressed patients. A 61 year old female was successfully treated with moxifloxacin and doxycycline combination therapy for an infected hematoma secondary to following a renal transplant. Microbiology technologists noted the growth of pinpoint, translucent non-hemolytic colonies, but no organisms seen on Gram stain. These findings prompted the updated culture report of, "Growth on culture plates, gram stain suggestive of organism lacking cell wall." Empiric antimicrobials were initiated to cover both spp. and spp before resulting . Initiating empiric therapy directed against spp. following Gram stain results and before organism speciation may prevent a lapse in effective therapy. This is especially important as perioperative antimicrobial prophylaxis regimens consist of beta-lactam regimens directed against common GI and GU pathogens, which lack activity against spp.
某些物种,特别是(),通常与泌尿生殖道(GU)感染综合征相关。然而, spp. 也可参与生殖器外感染,主要发生在免疫抑制患者中。一名61岁女性因肾移植后继发的感染性血肿,接受莫西沙星和强力霉素联合治疗,治疗成功。微生物技术人员注意到针尖状、半透明非溶血菌落生长,但革兰氏染色未发现细菌。这些发现促使更新后的培养报告为“培养平板上生长,革兰氏染色提示缺乏细胞壁的细菌”。在结果出来之前,开始使用经验性抗菌药物覆盖 spp. 和 spp.。在革兰氏染色结果出来后且在细菌鉴定之前开始针对 spp. 的经验性治疗,可能会防止有效治疗出现中断。这一点尤为重要,因为围手术期抗菌预防方案由针对常见胃肠道和泌尿生殖道病原体的β-内酰胺类方案组成,这些方案对 spp. 缺乏活性。