曼陀罗属植物提取物治疗银屑病的疗效：病例系列和单臂研究的荟萃分析。

Efficacy of extracts from Datura Metel L. for Psoriasis: a meta-analysis of case series and single-arm studies.

机构信息

Longgang Key Laboratory of Chinese Medicine and Immunology, Shenzhen Hospital, Beijing University of Chinese Medicine, Shenzhen, Guangdong, 518100, China.

出版信息

BMC Complement Med Ther. 2023 Sep 14;23(1):320. doi: 10.1186/s12906-023-04159-6.

DOI:10.1186/s12906-023-04159-6

PMID:37710189

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10500872/

Abstract

BACKGROUND

Datura Metel L. has been used to treat psoriasis in China for a long time. The effect of extracts from Datura Metel L. for Psoriasis has not been previously confirmed. This study aimed to evaluate the efficacy of extracts from Datura Metel L. for patients with psoriasis.

METHODS

PubMed, Cochrane Library, Embase, and other databases were searched from database inception until to September 1, 2021. A quality assessment and data extraction were performed by 2 independent reviews. We used a random-effects meta-analysis model to estimate the pooled curative effect, pooled odds ratio (OR), and 95% confidence intervals.

RESULTS

Nine studies were included in Meta-analysis, including a total number of 1778 patients with psoriasis. The case cure rate of Datura Metel L. intravenous therapy was 0.48 (95% CI: 0.33, 0.62) and of Datura Metel L. oral therapy was 0.42 (95% CI: 0.17, 0.68), respectively. The case effective rate of Datura Metel L. intravenous therapy was 0.91 (95% CI: 0.84, 0.97) and of Datura Metel L. oral therapy was 0.94 (95% CI: 0.88, 0.99), respectively.

CONCLUSIONS

The extracts from Datura Metel L. showed the potential to treat psoriasis, and intravenous therapy might be a promising treatment to cure psoriasis, which is likely affected by selection and publication bias, still need more high quality clinical studies.

摘要

背景

曼陀罗在中国长期以来一直被用于治疗银屑病。曼陀罗提取物治疗银屑病的效果以前尚未得到证实。本研究旨在评估曼陀罗提取物治疗银屑病患者的疗效。

方法

从数据库成立到 2021 年 9 月 1 日，检索了 PubMed、Cochrane Library、Embase 和其他数据库。由 2 位独立评审员进行质量评估和数据提取。我们使用随机效应荟萃分析模型来估计汇总疗效、汇总优势比（OR）和 95%置信区间。

结果

纳入了 9 项研究进行荟萃分析，共包括 1778 例银屑病患者。曼陀罗静脉治疗的病例治愈率为 0.48（95%CI：0.33，0.62），曼陀罗口服治疗的病例治愈率为 0.42（95%CI：0.17，0.68）。曼陀罗静脉治疗的病例有效率为 0.91（95%CI：0.84，0.97），曼陀罗口服治疗的病例有效率为 0.94（95%CI：0.88，0.99）。