Longgang Key Laboratory of Chinese Medicine and Immunology, Shenzhen Hospital, Beijing University of Chinese Medicine, Shenzhen, Guangdong, 518100, China.
BMC Complement Med Ther. 2023 Sep 14;23(1):320. doi: 10.1186/s12906-023-04159-6.
Datura Metel L. has been used to treat psoriasis in China for a long time. The effect of extracts from Datura Metel L. for Psoriasis has not been previously confirmed. This study aimed to evaluate the efficacy of extracts from Datura Metel L. for patients with psoriasis.
PubMed, Cochrane Library, Embase, and other databases were searched from database inception until to September 1, 2021. A quality assessment and data extraction were performed by 2 independent reviews. We used a random-effects meta-analysis model to estimate the pooled curative effect, pooled odds ratio (OR), and 95% confidence intervals.
Nine studies were included in Meta-analysis, including a total number of 1778 patients with psoriasis. The case cure rate of Datura Metel L. intravenous therapy was 0.48 (95% CI: 0.33, 0.62) and of Datura Metel L. oral therapy was 0.42 (95% CI: 0.17, 0.68), respectively. The case effective rate of Datura Metel L. intravenous therapy was 0.91 (95% CI: 0.84, 0.97) and of Datura Metel L. oral therapy was 0.94 (95% CI: 0.88, 0.99), respectively.
The extracts from Datura Metel L. showed the potential to treat psoriasis, and intravenous therapy might be a promising treatment to cure psoriasis, which is likely affected by selection and publication bias, still need more high quality clinical studies.
曼陀罗在中国长期以来一直被用于治疗银屑病。曼陀罗提取物治疗银屑病的效果以前尚未得到证实。本研究旨在评估曼陀罗提取物治疗银屑病患者的疗效。
从数据库成立到 2021 年 9 月 1 日，检索了 PubMed、Cochrane Library、Embase 和其他数据库。由 2 位独立评审员进行质量评估和数据提取。我们使用随机效应荟萃分析模型来估计汇总疗效、汇总优势比（OR）和 95%置信区间。
纳入了 9 项研究进行荟萃分析，共包括 1778 例银屑病患者。曼陀罗静脉治疗的病例治愈率为 0.48（95%CI：0.33，0.62），曼陀罗口服治疗的病例治愈率为 0.42（95%CI：0.17，0.68）。曼陀罗静脉治疗的病例有效率为 0.91（95%CI：0.84，0.97），曼陀罗口服治疗的病例有效率为 0.94（95%CI：0.88，0.99）。
曼陀罗提取物具有治疗银屑病的潜力，静脉治疗可能是一种有前途的治疗银屑病的方法，但可能受到选择和发表偏倚的影响，仍需要更多高质量的临床研究。
