莨菪烷类生物碱，从曼陀罗中提取，通过 STAT3/P38/ERK1/2 通路抑制角质形成细胞增殖和咪喹莫特诱导的银屑病样皮炎。

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China.

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, 280 Outer Ring Road, University Town, Guangzhou 510006, China.

Molecules. 2019 Jul 17;24(14):2596. doi: 10.3390/molecules24142596.

Psoriasis is an immune-mediated inflammatory dermatosis characterized by epidermal hyperplasia and excessive infiltration of inflammatory cells. Withanolides, extracted from L.; are the main effective components for the treatment of psoriasis. However, the precise mechanisms of action of withanolides for the treatment of psoriasis remain unclear. We found that treatment with withanolides alleviated imiquimod (IMQ)-induced epidermal hyperplasia and inflammatory cell infiltration in the effective skin of model mice. In addition, we also found that withanolides suppressed the activation of STAT3, ERK1/2 and P38 signaling pathways in IMQ-stimulated HaCat cells. These results suggest that withanolides possess an anti-inflammatory effect and have significant therapeutic potential for the prevention and treatment of psoriasis.

银屑病是一种免疫介导的炎症性皮肤病，其特征是表皮过度增生和炎症细胞过度浸润。来自 L. 的 withanolides 是治疗银屑病的主要有效成分。然而，withanolides 治疗银屑病的确切作用机制尚不清楚。我们发现，withanolides 治疗可减轻咪喹莫特（IMQ）诱导的模型小鼠有效皮肤的表皮过度增生和炎症细胞浸润。此外，我们还发现 withanolides 抑制了 IMQ 刺激的 HaCat 细胞中 STAT3、ERK1/2 和 P38 信号通路的激活。这些结果表明，withanolides 具有抗炎作用，对预防和治疗银屑病具有重要的治疗潜力。