Ben Amar M, L'Espérance G, Tawashi R
Int Urol Nephrol. 1986;18(3):227-33. doi: 10.1007/BF02082708.
The effect of 3 hydroxamic acid derivatives on urease-induced crystalluria was studied in vitro. Acetohydroxamic acid is more effective than salicylhydroxamic and gentisohydroxamic acids in inhibiting the kinetic of urease enzymatic reaction and in retarding the formation of struvite and apatite. Crystal deposits studied by scanning electron microscope (S.E.M.) and X-ray microanalysis indicated that acetohydroxamic acid favours the formation of large crystals of struvite, and less aggregation is observed. Salicyl and gentiso derivatives favour the formation of brushite together with struvite and apatite.
在体外研究了3种异羟肟酸衍生物对脲酶诱导的结晶尿的影响。乙酰异羟肟酸在抑制脲酶酶促反应动力学以及延缓鸟粪石和磷灰石形成方面比水杨羟肟酸和龙胆羟肟酸更有效。通过扫描电子显微镜（S.E.M.）和X射线微分析研究的晶体沉积物表明，乙酰异羟肟酸有利于鸟粪石大晶体的形成，并且观察到较少的聚集。水杨衍生物和龙胆衍生物有利于透钙磷石与鸟粪石和磷灰石一起形成。
