Burr R G, Nuseibeh I
Br J Urol. 1983 Apr;55(2):162-5. doi: 10.1111/j.1464-410x.1983.tb06545.x.
Chronic urinary infection is thought to be a major factor in the causation of urinary calculi in paraplegic patients. Acetohydroxamic acid is reported to be effective in some patients for the management of this type of stone disease, but there have been no studies of urinary saturation levels during therapy with this drug. In this study 10 patients received oral acetohydroxamic acid for seven days. Marked lowering of urinary pH and ammonium levels were observed, but decreases in urinary saturation were small. The administration of acetohydroxamic acid resulted in increased urinary excretion of magnesium and phosphate, effects that have not previously been reported.
慢性尿路感染被认为是截瘫患者尿路结石形成的主要因素。据报道，乙酰氧肟酸对某些患有此类结石病的患者有效，但尚无关于该药物治疗期间尿液饱和度水平的研究。在本研究中，10名患者口服乙酰氧肟酸7天。观察到尿液pH值和铵水平显著降低，但尿液饱和度的降低幅度较小。乙酰氧肟酸的给药导致尿液中镁和磷酸盐的排泄增加，这是此前未曾报道过的效应。
