Migliorelli Andrea, Caranti Alberto, Manuelli Marianna, Bianchini Chiara, Ciorba Andrea, Pelucchi Stefano
Department of Neurosciences and Rehabilitation, ENT and Audiology Unit, University Hospital of Ferrara, Ferrara, Italy.
Ann Maxillofac Surg. 2023 Jan-Jun;13(1):95-97. doi: 10.4103/ams.ams_135_22. Epub 2023 Mar 27.
The aim of this study is to describe a rare case of clear-cell renal cell carcinoma (ccRCC) metastasis to the pterygomaxillary fossa.
A 54-year-old woman was referred to the Department of Otolaryngology due to right facial pain for the past six weeks.
ccRCC metastasis to the pterygomaxillary fossa.
The patient was treated by immunotherapy (Ipilimumab + Nivolumab) after multidisciplinary team evaluation.
After 18 months, the patient is in good overall condition and the size of the skull base lesion has significantly reduced.
TAKE-AWAY LESSONS: ccRCC metastasis to the skull base and adjacent sites occur rarely. Most commonly, the presenting symptoms of these lesions are headache and diplopia for skull base metastases and epistaxis in case of sinusal involvement, according to the literature. When total resection of the metastasis is not feasible, tumour-targeted therapy may be used, as in the presented case. A multidisciplinary evaluation is recommended for the correct assessment and management of these patients.
本研究的目的是描述一例罕见的透明细胞肾细胞癌（ccRCC）转移至翼腭窝的病例。
一名54岁女性因过去六周右侧面部疼痛被转诊至耳鼻喉科。
ccRCC转移至翼腭窝。
经过多学科团队评估后，该患者接受了免疫治疗（伊匹单抗+纳武单抗）。
18个月后，患者总体状况良好，颅底病变大小显著减小。
ccRCC转移至颅底及相邻部位的情况很少见。根据文献，这些病变最常见的症状是颅底转移时的头痛和复视，以及鼻窦受累时的鼻出血。当转移灶无法完全切除时，可采用肿瘤靶向治疗，如本病例所示。建议对这些患者进行多学科评估，以进行正确的评估和管理。
