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原发性不明的癌肿导致快速进展性自发性血胸:1例极为罕见的病例。

Rapid progressive spontaneous hemothorax caused by carcinoma of unknown primary: A very rare case.

作者信息

Koike Sachie, Kobayashi Nobutaka, Miyazawa Masahisa, Yamashita Naho

机构信息

Department of Thoracic Surgery Japanese Red Cross Society Nagano hospital Nagano Japan.

Division of General Thoracic Surgery, Department of Surgery Shinshu University School of Medicine Matsumoto Japan.

出版信息

Respirol Case Rep. 2023 Sep 12;11(10):e01215. doi: 10.1002/rcr2.1215. eCollection 2023 Oct.

DOI:10.1002/rcr2.1215
PMID:37711652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10497902/
Abstract

We present a very rare case of spontaneous hemothorax which was caused by carcinoma of unknown primary. To the best of our knowledge, there are no other such cases reported worldwide. The patient was 72-year-old male who was referred to our department for massive hemothorax. We undertook surgical treatment for haemostasis, and found multiple tumours which led to the diagnosis of carcinoma of unknown primary as the cause of haemorrhage. The tumours increased and grew rapidly after surgery and hemothorax progressed despite our treatment. The patient died from disseminated intravascular coagulation caused by continuous bleeding on postoperative day 19.

摘要

我们报告了一例极为罕见的自发性血胸病例,其病因是原发性不明的癌症。据我们所知,全球尚无其他此类病例报告。该患者为一名72岁男性,因大量血胸转诊至我科。我们进行了手术止血,发现了多个肿瘤,从而诊断原发性不明癌症为出血原因。术后肿瘤增多且生长迅速,尽管我们进行了治疗,血胸仍有进展。患者于术后第19天因持续出血导致弥散性血管内凝血而死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/10497902/6e96fdb3d2ab/RCR2-11-e01215-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/10497902/1ed470360cd5/RCR2-11-e01215-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/10497902/6e96fdb3d2ab/RCR2-11-e01215-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/10497902/1ed470360cd5/RCR2-11-e01215-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07a6/10497902/6e96fdb3d2ab/RCR2-11-e01215-g003.jpg

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本文引用的文献

1
Cancer of unknown primary: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.原发灶不明癌:ESMO 诊断、治疗及随访临床实践指南
Ann Oncol. 2023 Mar;34(3):228-246. doi: 10.1016/j.annonc.2022.11.013. Epub 2022 Dec 20.
2
WITHDRAWN: Chest Trauma: First 48 hours management.撤回:胸部创伤:最初48小时的管理
Anaesth Crit Care Pain Med. 2017 Jan 18. doi: 10.1016/j.accpm.2017.01.004.
3
Etiology and management of spontaneous haemothorax.自发性血胸的病因及处理
J Thorac Dis. 2015 Mar;7(3):520-6. doi: 10.3978/j.issn.2072-1439.2014.12.50.
4
Cancers of unknown primary site: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.原发部位不明的癌症:ESMO诊断、治疗及随访临床实践指南
Ann Oncol. 2011 Sep;22 Suppl 6:vi64-8. doi: 10.1093/annonc/mdr389.
5
Spontaneous hemothorax: a comprehensive review.自发性血胸:综述
Chest. 2008 Nov;134(5):1056-1065. doi: 10.1378/chest.08-0725.