用依库珠单抗成功治疗难治性全身型重症肌无力合并肌无力性不完全性眼肌麻痹

Refractory generalized myasthenia gravis with myasthenic incomplete ophthalmoplegia successfully treated with eculizumab.

作者信息

Weidmayer Sara L, Gallagher Gary

机构信息

LTC Charles S. Kettles VA Medical Center, VA Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI, United States.

WK Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, 1000 Wall Street, Ann Arbor, MI, United States.

出版信息

Am J Ophthalmol Case Rep. 2023 Sep 7;32:101925. doi: 10.1016/j.ajoc.2023.101925. eCollection 2023 Dec.

DOI:10.1016/j.ajoc.2023.101925

PMID:37711751

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10498161/

Abstract

PURPOSE

This is a case of myasthenic incomplete ophthalmoplegia mimicking a partial cranial nerve 3 palsy both subjectively and objectively improving after treatment with eculizumab.

OBSERVATIONS

We chronicle a case of severe generalized myasthenia gravis including myasthenia masquerading as a partial cranial nerve 3 palsy, refractory to pyridostigmine, mycophenolate, prednisone, intravenous immunoglobulin and plasma exchange but responsive to eculizumab.

CONCLUSIONS AND IMPORTANCE

This case demonstrates ocular and generalized myasthenia gravis refractory to several other therapies but amenable to eculizumab infusions, suggesting this medication may be of significant value in these difficult cases, and should be further explored for refractory ocular myasthenia gravis.

摘要