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心血管支架:类型与未来前景

Cardiovascular Stents: Types and Future Landscape.

作者信息

Sahu Rohit A, Nashine Aparna, Mudey Abhay, Sahu Shreya A, Prasad Roshan

机构信息

Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

Obstretics and Gynecology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

出版信息

Cureus. 2023 Aug 13;15(8):e43438. doi: 10.7759/cureus.43438. eCollection 2023 Aug.

DOI:10.7759/cureus.43438
PMID:37711918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10499059/
Abstract

One of the prominent reasons for mortality and morbidity worldwide is coronary artery disease (CAD), an ailment that manifests itself by the narrowing of the artery with the deposition of plaque. The definitive mode of action for dealing with this condition is using a medical device known as a stent at the affected location. This extremely important tubular equipment helps tremendously with vessel support. It also helps by keeping the path of blood flow clear for the heart muscle masses, its crucial nutrients, and oxygen supply. Several generations of stents have been continuously developed to improve patient outcomes and reduce side effects post-stent implantation. As we move from bare metal stents (BMSs) to drug-eluting stents (DESs) and, more recently, to bioabsorbable stents, the research area continues to develop. The use of this biomedical device has increased the standard of living in many cases; therefore, it is much needed to work on the possible growth areas in the cardiovascular stents and improve them to such an extent that the patients suffering from cardiovascular ailments get to live a comfortable life. Most articles deal with stents that are available for current use and their various types. They also cover the topic of stent optimization, as it is one of the key factors in enhancing stent usability and plays a prominent role in optimizing stent placement in the vessels of the body. To keep in touch with advances in stent technology over the past few decades, this article reviews advances in the devices, working on how available stents can be optimized to create new stents.

摘要

冠状动脉疾病(CAD)是全球范围内导致死亡和发病的主要原因之一,这种疾病通过动脉粥样硬化斑块沉积导致动脉狭窄来表现自身。治疗这种疾病的决定性作用方式是在受影响部位使用一种称为支架的医疗器械。这种极其重要的管状设备对血管支撑有极大帮助。它还通过为心肌组织、其关键营养物质和氧气供应保持血流路径畅通来发挥作用。几代支架不断得到开发,以改善患者预后并减少支架植入后的副作用。随着我们从裸金属支架(BMS)发展到药物洗脱支架(DES),以及最近发展到生物可吸收支架,该研究领域持续发展。在许多情况下,这种生物医学设备的使用提高了生活水平;因此,非常有必要研究心血管支架可能的增长领域,并将其改进到使患有心血管疾病的患者能够过上舒适生活的程度。大多数文章讨论的是当前可用的支架及其各种类型。它们还涵盖了支架优化的主题,因为这是提高支架可用性的关键因素之一,并且在优化支架在人体血管中的放置方面发挥着重要作用。为了跟上过去几十年支架技术的进步,本文回顾了这些设备的进展,探讨如何优化现有支架以制造新的支架。

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1
Cardiovascular Stents: Types and Future Landscape.心血管支架:类型与未来前景
Cureus. 2023 Aug 13;15(8):e43438. doi: 10.7759/cureus.43438. eCollection 2023 Aug.
2
Cardiovascular Stents: A Review of Past, Current, and Emerging Devices.心血管支架:过去、当前及新兴器械综述
Materials (Basel). 2021 May 12;14(10):2498. doi: 10.3390/ma14102498.
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Stenting for peripheral artery disease of the lower extremities: an evidence-based analysis.下肢外周动脉疾病的支架置入术:一项基于证据的分析。
Ont Health Technol Assess Ser. 2010;10(18):1-88. Epub 2010 Sep 1.
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Efficacy and Safety of Drug-Eluting Stents Optimized for Biocompatibility vs Bare-Metal Stents With a Single Month of Dual Antiplatelet Therapy: A Meta-analysis.药物洗脱支架优化生物相容性与裸金属支架对比双联抗血小板治疗 1 个月:Meta 分析。
JAMA Cardiol. 2018 Nov 1;3(11):1050-1059. doi: 10.1001/jamacardio.2018.3551.
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Long-term outcome of patients with very small coronary artery disease: A comparison of drug-eluting and bare metal stents.极小冠状动脉疾病患者的长期预后:药物洗脱支架与裸金属支架的比较
J Chin Med Assoc. 2016 Dec;79(12):642-648. doi: 10.1016/j.jcma.2016.04.010. Epub 2016 Sep 29.
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Comparison of drug-eluting and bare-metal stents in patients with diabetes undergoing primary percutaneous coronary intervention: what is the evidence?糖尿病患者接受直接经皮冠状动脉介入治疗时药物洗脱支架与裸金属支架的比较:证据是什么?
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Coronary artery stents: a rapid systematic review and economic evaluation.冠状动脉支架:一项快速系统评价与经济学评估
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A comprehensive meta-analysis of randomized controlled trials comparing drug-eluting stents with bare-metal stents in saphenous vein graft interventions.药物洗脱支架与金属裸支架在静脉桥血管介入治疗中比较的随机对照试验的综合荟萃分析。
Catheter Cardiovasc Interv. 2018 Dec 1;92(7):1229-1236. doi: 10.1002/ccd.27687. Epub 2018 Jul 26.

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Implantable Biosensors for Vascular Diseases: Directions for the Next Generation of Active Diagnostic and Therapeutic Medical Device Technologies.用于血管疾病的可植入生物传感器:下一代主动诊断和治疗医疗设备技术的发展方向。
Biosensors (Basel). 2025 Feb 25;15(3):147. doi: 10.3390/bios15030147.
2
Drug-eluting stents for coronary artery disease in the perspective of bibliometric analysis.基于文献计量分析视角的冠状动脉疾病药物洗脱支架研究
Front Cardiovasc Med. 2024 Feb 19;11:1288659. doi: 10.3389/fcvm.2024.1288659. eCollection 2024.

本文引用的文献

1
Cardiovascular Stents: A Review of Past, Current, and Emerging Devices.心血管支架:过去、当前及新兴器械综述
Materials (Basel). 2021 May 12;14(10):2498. doi: 10.3390/ma14102498.
2
Biodegradable- Versus Durable-Polymer Drug-Eluting Stents for STEMI: Final 2-Year Outcomes of the BIOSTEMI Trial.生物可降解聚合物药物洗脱支架与耐久性聚合物药物洗脱支架治疗 ST 段抬高型心肌梗死:BIOSTEMI 试验的最终 2 年结果。
JACC Cardiovasc Interv. 2021 Mar 22;14(6):639-648. doi: 10.1016/j.jcin.2020.12.011.
3
Designing Better Cardiovascular Stent Materials - A Learning Curve.
设计更好的心血管支架材料——一条学习曲线。
Adv Funct Mater. 2021 Jan 4;31(1). doi: 10.1002/adfm.202005361. Epub 2020 Nov 4.
4
Direct and Indirect Costs Associated with Coronary Artery (Heart) Disease in Tabriz, Iran.伊朗大不里士地区冠状动脉(心脏)病的直接和间接成本
Risk Manag Healthc Policy. 2020 Jul 31;13:969-978. doi: 10.2147/RMHP.S261612. eCollection 2020.
5
In vitro cytocompatibility, hemocompatibility and antibacterial properties of biodegradable Zn-Cu-Fe alloys for cardiovascular stents applications.用于心血管支架的可生物降解 Zn-Cu-Fe 合金的体外细胞相容性、血液相容性和抗菌性能。
Mater Sci Eng C Mater Biol Appl. 2020 Aug;113:111007. doi: 10.1016/j.msec.2020.111007. Epub 2020 Apr 22.
6
Experimental Tests, FEM Constitutive Modeling and Validation of PLGA Bioresorbable Polymer for Stent Applications.用于支架应用的聚乳酸-羟基乙酸共聚物(PLGA)生物可吸收聚合物的实验测试、有限元本构模型及验证
Materials (Basel). 2020 Apr 24;13(8):2003. doi: 10.3390/ma13082003.
7
Recent Advances in Manufacturing Innovative Stents.制造创新支架的最新进展
Pharmaceutics. 2020 Apr 13;12(4):349. doi: 10.3390/pharmaceutics12040349.
8
Mitophagy in Cardiovascular Diseases.心血管疾病中的线粒体自噬
J Clin Med. 2020 Mar 24;9(3):892. doi: 10.3390/jcm9030892.
9
Economic burden of coronary artery disease or peripheral artery disease in patients at high risk of ischemic events in the French setting: a claims database analysis.在法国,高缺血事件风险的患者中,冠心病或外周动脉疾病的经济负担:一项理赔数据库分析。
J Med Econ. 2020 May;23(5):513-520. doi: 10.1080/13696998.2020.1715415. Epub 2020 Jan 25.
10
Deep Learning in Personalization of Cardiovascular Stents.深度学习在心血管支架个性化定制中的应用
J Cardiovasc Pharmacol Ther. 2020 Mar;25(2):110-120. doi: 10.1177/1074248419878405. Epub 2019 Sep 25.