红景天苷通过干扰 HSP90 活性促进健康长寿。
Salidroside promotes healthy longevity by interfering with HSP90 activity.
机构信息
State Key Laboratory of Resource Insects, Key Laboratory of Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs, College of Sericulture, Textile and Biomass Science, Southwest University, Chongqing, 400715, China.
Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200, Copenhagen, Denmark.
出版信息
Geroscience. 2024 Apr;46(2):1641-1655. doi: 10.1007/s11357-023-00921-3. Epub 2023 Sep 15.
Aging is a risk factor for human health and quality of life. Screening and development of novel supplements and medications to combat aging and delay the incidence of age-related diseases are of great significance. In this study, salidroside (SA), a primary natural small molecule from Rhodiola rosea, was investigated regarding its effects on life and healthspan and the underlying molecular mechanism(s) of anti-aging and antioxidation. Our results showed that SA effectively prolonged lifespan and exhibited anti-aging and antioxidative properties. Computer-assisted methods, label-free interaction analysis, and in vitro assays showed that SA directly bound heat shock protein 90 (HSP90). Furthermore, SA significantly inhibited the ATPase activity of HSP90, affecting the interaction between HSP90 and its interacting proteins and the expression of downstream genes to regulate lifespan and the oxidative stress response. Our findings provided new insights into the pharmacological properties of SA across multiple species and its potential as an anti-aging drug.
衰老是影响人类健康和生活质量的一个重要因素。筛选和开发新型补充剂和药物来对抗衰老、延缓与年龄相关疾病的发生具有重要意义。在这项研究中，我们研究了来自红景天的主要天然小分子——红景天苷（SA）对寿命和健康跨度的影响及其抗衰老和抗氧化的潜在分子机制。结果表明，SA 能有效延长寿命，具有抗衰老和抗氧化特性。计算机辅助方法、无标记相互作用分析和体外测定表明，SA 能直接与热休克蛋白 90（HSP90）结合。此外，SA 能显著抑制 HSP90 的 ATP 酶活性，影响 HSP90 与其相互作用蛋白的相互作用以及下游基因的表达，从而调节寿命和氧化应激反应。我们的研究结果为 SA 在多种物种中的药理学特性及其作为抗衰老药物的潜力提供了新的见解。
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