Bruni J, Wilder B J, Willmore L J, Barbour B
Neurology. 1979 Jun;29(6):904-5. doi: 10.1212/wnl.29.6.904.
Eight patients were treated concurrently with a constant dose of phenytoin and valproic acid for 1 year. During initial therapy with valproic acid, total plasma phenytoin levels decreased. The interaction was transient and was not observed at the end of 1 year. Total plasma phenytoin levels returned to pre-valproic-acid levels in seven patients.
8名患者同时接受恒定剂量的苯妥英和丙戊酸治疗1年。在丙戊酸初始治疗期间，血浆苯妥英总水平下降。这种相互作用是短暂的，在1年末未观察到。7名患者的血浆苯妥英总水平恢复到丙戊酸治疗前的水平。
