连续进行游离和血浆丙戊酸及苯妥英监测以及药物相互作用监测。

Serial free and plasma valproic acid and phenytoin monitoring and drug interactions.

作者信息

Haidukewych D, Rodin E A

出版信息

Ther Drug Monit. 1981;3(3):303-7. doi: 10.1097/00007691-198103000-00013.

DOI:10.1097/00007691-198103000-00013

Abstract

In 12 institutionalized epilepsy patients who had been treated 19 months (SD +/- 5) with valproic acid, 27.0 mg/kg (SD +/- 11.9), phenytoin, 6.33 mg/kg (SD +/- 1.36), and co-anticonvulsants, the mean percentage of daily free valproic acid was 11.72 (SD +/- 2.10) and of phenytoin 20.39 (SD +/- 3.32). By serial within-day blood samplings for a.m., noon, and p.m. periods, the diurnal variation of percentage free valproic acid and phenytoin was determined for each patient. For morning and noon periods the variations in the percentages of free valproic acid and phenytoin were independent of each other, correlation coefficients (r) being zero for each period. In contrast, for early p.m. the correlation coefficient was highly significant at r = 0.894 (p less than 0.01). It is apparent that diurnal variations in the percentages of free valproic acid and phenytoin occur even in patients who have been treated with these compounds for more than a year.

摘要

在12例接受丙戊酸（剂量为27.0毫克/千克，标准差±11.9）、苯妥英（剂量为6.33毫克/千克，标准差±1.36）及联合抗惊厥药物治疗19个月（标准差±5）的住院癫痫患者中，每日游离丙戊酸的平均百分比为11.72（标准差±2.10），苯妥英为20.39（标准差±3.32）。通过在上午、中午和下午时间段进行日内连续采血，测定了每位患者游离丙戊酸和苯妥英百分比的昼夜变化。对于上午和中午时间段，游离丙戊酸和苯妥英百分比的变化相互独立，每个时间段的相关系数（r）均为零。相比之下，对于下午早些时候，相关系数r = 0.894，具有高度显著性（p < 0.01）。显然，即使是接受这些化合物治疗超过一年的患者，游离丙戊酸和苯妥英百分比也会出现昼夜变化。