注射速尿后内淋巴氯化物浓度的变化。

Changes in endolymph chloride concentration following furosemide injection.

作者信息

Rybak L P, Whitworth C

出版信息

Hear Res. 1986;24(2):133-6. doi: 10.1016/0378-5955(86)90057-2.

Abstract

Endocochlear potential (EP) and chloride concentration in endolymph were monitored with microelectrodes in the basal turn of the cochlea of the chinchilla. After intravenous injection of furosemide (25-100 mg/kg), the EP dropped precipitously and rapidly reached its minimum value, however, the chloride activity in endolymph decreased more gradually. Possible mechanisms for this phenomenon include a reduced electrostatic attraction of chloride ions to the scala media due to a decreased EP and a reduction of passive influx of chloride into endolymph, resulting from a reduction of active inward potassium transport by furosemide.

摘要

使用微电极监测了毛丝鼠耳蜗基部转弯处的内耳蜗电位（EP）和内淋巴中的氯离子浓度。静脉注射呋塞米（25 - 100mg/kg）后，EP急剧下降并迅速达到最小值，然而，内淋巴中的氯活性下降更为缓慢。这种现象的可能机制包括由于EP降低导致氯离子对中阶的静电吸引力降低，以及呋塞米使内向钾离子主动转运减少，从而导致氯离子向内淋巴的被动流入减少。