手性液相色谱固定相在药物分析中的最新进展。

Recent advances in chiral liquid chromatography stationary phases for pharmaceutical analysis.

机构信息

CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, China.

出版信息

J Chromatogr A. 2023 Oct 11;1708:464367. doi: 10.1016/j.chroma.2023.464367. Epub 2023 Sep 7.

DOI:10.1016/j.chroma.2023.464367

PMID:37714014

Abstract

Chirality is a common phenomenon in nature. Different enantiomers of chiral drug compounds have obvious differences in their effects on the human body. Therefore, the separation of chiral drugs plays an extremely important role in the safe utilization of drugs. High-performance liquid chromatography (HPLC) is an effective tool for the separation and analysis of compounds, in which the chromatographic packing plays a key role in the separation. Chiral pharmaceutical separation and analysis in HPLC rely on chiral stationary phases (CSPs). Thus, various CSPs are being developed to meet the needs of chiral drug separation and analysis. In this review, recent developments in CSPs, including saccharides (cyclodextrin, cellulose, amylose and chitosan), macrocycles (macrocyclic glycopeptides, pillar[n]arene and polyamide) and porous organic materials (metal-organic frameworks, covalent organic frameworks, and porous organic cages), for pharmaceutical analysis in HPLC were summarized, the advantages and disadvantages of various stationary phases were introduced, and their development prospects were discussed.

摘要

手性是自然界中的一种常见现象。手性药物化合物的对映异构体在对人体的作用方面存在明显差异。因此，手性药物的分离在药物的安全利用中起着极其重要的作用。高效液相色谱（HPLC）是化合物分离和分析的有效工具，其中色谱填料在分离中起着关键作用。HPLC 中的手性药物分离和分析依赖于手性固定相（CSP）。因此，正在开发各种 CSP 以满足手性药物分离和分析的需求。在本文综述中，总结了近年来用于 HPLC 中药物分析的 CSP 的最新发展，包括糖类（环糊精、纤维素、直链淀粉和壳聚糖）、大环（大环糖肽、柱芳烃和聚酰胺）和多孔有机材料（金属-有机框架、共价有机框架和多孔有机笼），介绍了各种固定相的优缺点，并讨论了它们的发展前景。