Cockcroft Shamshad
Department of Neuroscience, Physiology and Pharmacology, Division of Biosciences, University College London, 21 University Street, London WC1E 6JJ, UK.
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Mar;1869(2):159394. doi: 10.1016/j.bbalip.2023.159394. Epub 2023 Sep 13.
Phosphoinositides are phosphorylated derivatives of phosphatidylinositol, a phospholipid that is synthesised at the endoplasmic reticulum. The plasma membrane contains the enzymes to phosphorylate phosphatidylinositol and is therefore rich in the phosphorylated derivatives, PI4P and PI(4,5)P. PI(4,5)P is a substrate for phospholipase C and during cell signaling, PI(4,5)P levels are reduced. Here I discuss a family of proteins, phosphatidylinositol transfer proteins (PITPs) that can restore PI(4,5)P levels.
磷酸肌醇是磷脂酰肌醇的磷酸化衍生物，磷脂酰肌醇是一种在内质网合成的磷脂。质膜含有使磷脂酰肌醇磷酸化的酶，因此富含磷酸化衍生物PI4P和PI(4,5)P。PI(4,5)P是磷脂酶C的底物，在细胞信号传导过程中，PI(4,5)P水平会降低。在此，我将讨论一类能够恢复PI(4,5)P水平的蛋白质——磷脂酰肌醇转移蛋白（PITPs）。
