Radiology Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88, ChangLing Road, XiQing District, Tianjin, 300381, China.
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, No. 88, ChangLing Road, XiQing District, Tianjin, 300381, China.
Sci Rep. 2023 Sep 15;13(1):15298. doi: 10.1038/s41598-023-42570-8.
To explore the pathogenesis of Bell's palsy using the diffusion tensor image on 3.0 T MR. The healthy people and the patients with Bell's palsy underwent intraparotid facial nerve scanning by using the DTI and T1 structural sequence at 3.0 T MR. The raw DTI data were performed affine transformation and nonlinear registration in the common MNI152_T1 space and resampled to the 0.4 mm voxel size. A group of 4 spherical seed regions were placed on the intratemporal facial nerves in the common space, bilaterally and symmetrically. The DTI data in the common space were used to track the intratemporal facial nerve fibers by using TrackVis and its Diffusion Toolkit. Each tractography was used to construct the maximum probability map (MPM) according to the majority rule. The fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) were calculated and extracted on the basis of MPM. For healthy people, there was no significant difference in FA, MD, RD and AD of bilateral facial nerves. For patients with Bell's palsy, there was no significant difference in AD, there was significant difference in FA, MD and RD between the affected nerve and the healthy nerve (P < 0.02). This study showed that the myelin sheath injury of the intratemporal facial nerve is the main cause of Bell's palsy. Most neural axons are not damaged. The results may explain the pathogenesis of the Bell's palsy, which is self-limited for most cases.
使用 3.0T MR 的弥散张量成像技术探索贝尔面瘫的发病机制。健康人和贝尔面瘫患者均在 3.0T MR 上行腮腺内面神经弥散张量成像和 T1 结构序列扫描。原始 DTI 数据在共同的 MNI152_T1 空间进行仿射变换和非线性配准，并重新采样到 0.4mm 体素大小。在共同空间中，在双侧对称的颞内面神经上放置 4 个球形种子区。在共同空间中使用 TrackVis 和其弥散工具箱追踪颞内面神经纤维的 DTI 数据。根据多数原则，每个示踪轨迹都用于构建最大概率图（MPM）。在 MPM 的基础上计算并提取各向异性分数（FA）、平均弥散度（MD）、轴突弥散度（AD）和径向弥散度（RD）。对于健康人，双侧面神经的 FA、MD、RD 和 AD 无显著差异。对于贝尔面瘫患者，AD 无显著差异，患侧与健侧面神经的 FA、MD 和 RD 有显著差异（P<0.02）。本研究表明，颞内面神经的髓鞘损伤是贝尔面瘫的主要原因。大多数神经轴突未受损。这些结果可能解释了贝尔面瘫的发病机制，大多数情况下贝尔面瘫是自限性的。
