NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway.
NORMENT, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Norway; Department of Psychology, University of Oslo, Oslo, Norway.
Schizophr Res. 2023 Nov;261:80-93. doi: 10.1016/j.schres.2023.09.012. Epub 2023 Sep 15.
Research increasingly implicates glutamatergic dysfunction in the pathophysiologies of psychotic disorders. Auditory mismatch negativity (MMN) is an electroencephalography (EEG) waveform linked to glutamatergic neurotransmission and is consistently attenuated in schizophrenia (SCZ). MMN consists of two subcomponents, the repetition positivity (RP) and deviant negativity (DN) possibly reflecting different neural mechanisms. However, whether MMN reduction is present across different psychotic disorders, linked to distinct symptom clusters, or related to sex remain to be clarified.
Four hundred participants including healthy controls (HCs; n = 296) and individuals with SCZ (n = 39), bipolar disorder (BD) BD typeI (n = 35), or BD type II (n = 30) underwent a roving MMN paradigm and clinical evaluation. MMN, RP and DN as well their memory traces were recorded at the FCZ electrode. Analyses of variance and linear regression models were used both transdiagnostically and within clinical groups.
MMN was reduced in SCZ compared to BD (p = 0.006, d = 0.55) and to HCs (p < 0.001, d = 0.63). There was a significant group × sex interaction (p < 0.003) and the MMN impairment was only detected in males with SCZ. MMN amplitude correlated positively with Positive and Negative Syndrome Scale total score and negatively with Global Assessment of Functioning Scale score. The deviant negativity was impaired in males with SCZ. No group differences in memory trace indices of the MMN, DN, or RP.
MMN was attenuated in SCZ and correlated with greater severity of psychotic symptoms and lower level of functioning. Our results may indicate sex-dependent differences of glutamatergic function in SCZ.
研究越来越多地暗示谷氨酸能功能障碍与精神病性障碍的病理生理学有关。听觉失匹配负波（MMN）是一种与谷氨酸能神经传递有关的脑电图（EEG）波形，在精神分裂症（SCZ）中始终减弱。MMN 由两个子成分组成，重复正波（RP）和偏差负波（DN），可能反映不同的神经机制。然而，MMN 减少是否存在于不同的精神病性障碍中，与不同的症状群有关，或与性别有关，仍有待澄清。
共有 400 名参与者，包括健康对照组（HCs；n=296）和 SCZ 患者（n=39）、双相情感障碍 I 型（BDI；n=35）或双相情感障碍 II 型（BDII；n=30）接受了漫游 MMN 范式和临床评估。在 FCZ 电极上记录 MMN、RP 和 DN 及其记忆痕迹。使用方差分析和线性回归模型进行跨诊断和临床组内分析。
与 BD（p=0.006，d=0.55）和 HCs（p<0.001，d=0.63）相比，SCZ 患者的 MMN 减少。存在组间性别交互作用（p<0.003），仅在 SCZ 男性中检测到 MMN 损伤。MMN 振幅与阳性和阴性综合征量表总分呈正相关，与总体功能评估量表得分呈负相关。SCZ 男性的偏差负波受损。MMN、DN 或 RP 的记忆痕迹指标在各组之间无差异。
SCZ 患者的 MMN 减弱，与精神病症状严重程度和功能水平降低相关。我们的结果可能表明 SCZ 中谷氨酸能功能存在性别依赖性差异。
