Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Department of Anesthesia, McMaster University, Hamilton, ON, Canada; Department of Pediatrics, McMaster University, Hamilton, ON, Canada; Biostatistics Unit, Father Sean O'Sullivan Research Centre, St Joseph's Healthcare, Hamilton, ON, Canada; Centre for Development of Best Practices in Health, Yaoundé Central Hospital, Yaoundé, Cameroon; Department of Global Health, Stellenbosch University, Cape Town, South Africa.
Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Lancet HIV. 2023 Oct;10(10):e684-e689. doi: 10.1016/S2352-3018(23)00173-X. Epub 2023 Sep 13.
HIV drug resistance (HIVDR) is a major challenge to the effectiveness of antiretroviral therapy. Global efforts in addressing HIVDR require clear, transparent, and replicable reporting in HIVDR studies. We describe the rationale and recommended use of a checklist that should be included in reports of HIVDR incidence and prevalence. After preliminary consultations with experts on HIVDR and establishing the need for guidance on HIVDR reporting, we used a sequential, explanatory, mixed methods approach to create the checklist; together with the accompanying articles, the checklist was reviewed by the authors and validated externally. The checklist for studies on HIVDR prevalence or incidence (CEDRIC-HIV) includes 15 recommended items that would enhance transparency and facilitate interpretation, comparability, and replicability of HIVDR studies. CEDRIC-HIV will help authors of HIVDR studies prepare research reports and assist reviewers and editors in assessments of completeness of reporting. The checklist will also facilitate statistical pooling and interpretation of HIVDR data.
HIV 耐药性（HIVDR）是抗逆转录病毒疗法有效性的主要挑战。全球应对 HIVDR 的努力需要在 HIVDR 研究中进行清晰、透明和可复制的报告。我们描述了一份清单的基本原理和推荐使用方法，该清单应包含在 HIVDR 发生率和流行率的报告中。在与 HIVDR 专家进行初步磋商并确定需要 HIVDR 报告指南后，我们使用了顺序、解释性、混合方法来创建清单；清单和配套文章一起由作者进行了审查，并进行了外部验证。HIVDR 流行率或发生率研究的清单（CEDRIC-HIV）包括 15 项建议项目，这些项目将提高透明度，并有助于解释、比较和复制 HIVDR 研究。CEDRIC-HIV 将帮助 HIVDR 研究的作者准备研究报告，并协助审查员和编辑评估报告的完整性。该清单还将促进 HIVDR 数据的统计汇总和解释。
