Mark-Wagstaff Charlotte, Deshmukh Harshal, Wilmot Emma G, Walker Neil, Barnes Dennis, Parfitt Vernon, Saunders Simon, Gregory Rob, Choudhary Pratik, Patmore Jane, Walton Chris, Ryder Robert E J, Sathyapalan Thozhukat
Hull University Teaching Hospitals NHS Trust, Hull, UK.
University of Hull, Hull, UK.
Diabetes Obes Metab. 2024 Jan;26(1):46-53. doi: 10.1111/dom.15283. Epub 2023 Sep 17.
Frequent hypoglycaemia results in disruption to usual hypoglycaemic autonomic responses leading to impaired awareness of hypoglycaemia, which is associated with an increased risk of severe hypoglycaemia requiring third-party assistance (SH). The UK Driving and Vehicle Licensing Agency (DVLA) does not permit car driving if they have either a complete loss of hypoglycaemia awareness or more than one SH event a year.
The FreeStyle Libre (FSL) Association of British Clinical Diabetologists (ABCD) Nationwide Audit consists of data collected by clinicians during routine clinical work, submitted into a secure web-based tool held within the National Health Service (NHS) N3 network. Analysis of paired baseline and follow-up data for people with type 1 diabetes who also held a driving licence was undertaken.
The study consisted of 6304 people who had data recorded about driving status from 102 UK specialist diabetes centres, of which 4218 held a driving licence: 4178 a group 1, standard licence, 33 a group 2, large lorries and buses, seven a taxi licence; 1819 did not drive. Paired baseline and follow-up data were available for a sub-cohort of 1606/4218. At a mean follow-up of 6.9 months [95% CI (6.8, 7.1)], the Gold score had improved (2.3 ± 1.5 vs. 2.0 ± 1.3 p < .001), and the number of people who experienced an SH episode was also significantly lower (12.1% vs. 2.7%, p < .001).
This study suggests that intermittently scanned continuous glucose monitoring may improve impaired awareness of hypoglycaemia and reduce the number of people with type 1 diabetes with a driving licence experiencing a severe hypoglycaemic episode.
频繁低血糖会导致正常的低血糖自主神经反应中断,进而导致低血糖意识受损,这与需要第三方协助的严重低血糖(SH)风险增加有关。英国驾驶与车辆牌照局(DVLA)规定,如果患者完全丧失低血糖意识或每年发生超过一次SH事件,则不允许其驾驶汽车。
英国临床糖尿病学家协会(ABCD)的FreeStyle Libre(FSL)全国性审计收集了临床医生在日常临床工作中收集的数据,并提交至国民健康服务(NHS)N3网络中的一个安全的基于网络的工具中。对同时持有驾驶执照的1型糖尿病患者的配对基线数据和随访数据进行了分析。
该研究纳入了6304名来自英国102个专业糖尿病中心且记录了驾驶状态数据的患者,其中4218人持有驾驶执照:4178人持有1类标准执照,33人持有2类大型货车和巴士执照,7人持有出租车执照;1819人不驾车。1606/4218的亚组有配对的基线数据和随访数据。在平均6.9个月的随访期[95%CI(6.8,7.1)]内,金氏评分有所改善(2.3±1.5对2.0±1.3,p<.001),经历SH事件的人数也显著减少(12.1%对2.7%,p<.001)。
本研究表明,间歇性扫描式持续葡萄糖监测可能会改善低血糖意识受损的情况,并减少持有驾驶执照的1型糖尿病患者发生严重低血糖事件的人数。