疱疹样皮炎相关小肠病的冷冻断裂研究：与乳糜泻的对比调查

A freeze-fracture study of the enteropathy associated with dermatitis herpetiformis: a comparative investigation with coeliac disease.

作者信息

Contini D, Torti A, Monti M, Caputo R, Gasparini G, Vecchi M, de Franchis R

出版信息

J Cutan Pathol. 1986 Aug;13(4):293-300. doi: 10.1111/j.1600-0560.1986.tb01525.x.

DOI:10.1111/j.1600-0560.1986.tb01525.x

Abstract

Jejunal biopsies from patients with either dermatitis herpetiformis or coeliac disease were freeze-fractured and compared with normal jejunal biopsies. The intestinal mucosa of the normal biopsies showed a normal structure, with well-developed and tightly packed microvilli; in dermatitis herpetiformis and coeliac disease degenerative changes of the intestinal mucosa occurred. These changes appeared to be segmental in dermatitis herpetiformis and diffuse in coeliac disease. Emphasis is placed on changes in the tight junctional net at the base of the microvilli, which could represent cellular damage related to increased intestinal permeability to macromolecules in these diseases. An interpretative hypothesis for these observations is presented.

摘要

对患有疱疹样皮炎或乳糜泻的患者的空肠活检组织进行冷冻断裂处理，并与正常空肠活检组织进行比较。正常活检组织的肠黏膜结构正常，微绒毛发育良好且紧密排列；而在疱疹样皮炎和乳糜泻中，肠黏膜出现了退行性变化。这些变化在疱疹样皮炎中似乎是节段性的，在乳糜泻中则是弥漫性的。重点关注微绒毛基部紧密连接网络的变化，这可能代表了这些疾病中与肠道对大分子通透性增加相关的细胞损伤。本文提出了对这些观察结果的解释性假说。