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在一名接受原位肝移植的患者中,使用艾达赛珠单抗逆转达比加群后发生围手术期心肌梗死

Perioperative Myocardial Infarction Following Dabigatran Reversal With Idarucizumab in a Patient Undergoing Orthotopic Liver Transplantation.

作者信息

Barroso Alex, Martinez-Gonzalez M Carmen, Knowlson Nathanael, Miguel Alba M, Perez Gonzalo

机构信息

Anesthesiology and Reanimation, Hospital Regional Universitario de Málaga, Málaga, ESP.

Intensive Care Unit, Hospital Regional Universitario de Málaga, Málaga, ESP.

出版信息

Cureus. 2023 Aug 15;15(8):e43531. doi: 10.7759/cureus.43531. eCollection 2023 Aug.

Abstract

Insufficient information is available regarding the administration of anticoagulants, specifically direct oral anticoagulants, in individuals with cirrhosis awaiting liver transplantation. In this report, we present a case of a 66-year-old male with atrial fibrillation treated with dabigatran who received idarucizumab prior to orthotopic liver transplantation. Hemostatic status was monitored throughout the procedure with both conventional hemostatic tests and point-of-care viscoelastic hemostatic assays. The patient suffered an intraoperative myocardial infarction, which could be related to the use of idarucizumab.

摘要

关于在等待肝移植的肝硬化患者中使用抗凝剂,特别是直接口服抗凝剂的信息不足。在本报告中,我们介绍了一例66岁患有心房颤动的男性患者,该患者接受达比加群治疗,并在原位肝移植前接受了依达赛珠单抗治疗。在整个手术过程中,通过传统的止血测试和即时粘弹性止血分析来监测止血状态。该患者术中发生心肌梗死,这可能与依达赛珠单抗的使用有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e0a/10503784/b84c02961377/cureus-0015-00000043531-i01.jpg

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