Flynn M A, Nolph G B, Osio Y, Sun G Y, Lanning B, Krause G, Dally J C
J Am Diet Assoc. 1986 Nov;86(11):1541-8.
This study shows the variability of response of serum cholesterol to whole food dietary cholesterol eaten by free-living people. Divided into two groups in a crossover design, normolipemic, healthy volunteers in Group A showed statistically significant increases in mean serum cholesterol after eating three eggs daily for 10 weeks (p less than or equal to .01) and a significant decrease within 2 weeks of crossover to eating no eggs (p less than or equal to .03). Group B exhibited a significant decrease in mean serum cholesterol after eating no eggs for 12 weeks (p less than or equal to .02) but, after crossing over to eating 3 eggs daily for 10 weeks, showed no longitudinally significant increases. Only Group A showed statistically significant changes in mean high-density-lipoprotein cholesterol, i.e., an increase at the end of 12 weeks of eating three eggs daily (p less than or equal to .001). Mean serum triglycerides showed no significant change.
本研究显示了自由生活人群食用全食物膳食胆固醇后血清胆固醇反应的变异性。在交叉设计中分为两组，A组血脂正常的健康志愿者在每天吃三个鸡蛋10周后，平均血清胆固醇有统计学意义的显著升高（p≤0.01），在交叉到不吃鸡蛋的2周内显著下降（p≤0.03）。B组在不吃鸡蛋12周后平均血清胆固醇显著下降（p≤0.02），但在交叉到每天吃3个鸡蛋10周后，纵向没有显著升高。只有A组平均高密度脂蛋白胆固醇有统计学意义的显著变化，即每天吃三个鸡蛋12周结束时升高（p≤0.001）。平均血清甘油三酯无显著变化。
