Zareef Rana, Salameh Elio, Hammoud Rawan, Tannouri Theresia, Bitar Fadi, Arabi Mariam
Pediatric and Adolescent Medicine Department, American University of Beirut Medical Center, Beirut, Lebanon.
Faculty of Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Front Cardiovasc Med. 2023 Aug 31;10:1235165. doi: 10.3389/fcvm.2023.1235165. eCollection 2023.
COVID-19 pandemic has spread widely at unpreceded pace. Cardiovascular comorbidities are significantly correlated with severe and critical illness. Nevertheless, studies examining the impact of congenital heart disease on COVID-19 severity are scarce and restricted to hospitalized patients. This study aims to explore the course of COVID-19 illness, severity and complications in patients with concomitant congenital heart disease.
This study is a cross sectional survey that includes patients with congenital heart disease who are registered at the Children Heart Center at the American University of Beirut Medical Center. The survey was conducted in the pediatric cardiology outpatient clinics or remotely via phone calls.
A total of 238 patients participated in the study, of which 47.9% had suspected or confirmed diagnosis of SARS-CoV-2 infection. The majority of patients had mild illness. The symptoms ranged between rhinorrhea (15.6%), cough (15.6%), low-grade fever (11.2%), anosmia (2.7%), ageusia (2.5%), headache (9.8%), high-grade fever (8.5%), gastrointestinal symptoms (7.6%), lethargy (6.3%), muscle aches (5.6%), difficulty breathing (5.4%), joint pain (4.7%), and chills (4.7%). 20% of the surveyed patients required treatment at home. Hospitalization and oxygen therapy was required in 3.5% of cases, while only 1.5% demanded intensive care admission. Only one fatality was encountered.
COVID-19 infection in pateints with congenital heart disease exhibits a mild to moderate course, and doesn't necessarily increase risk of complicated disease. No correlation could be found between specific congenital heart lesion and disease severity.
新冠疫情以前所未有的速度广泛传播。心血管合并症与重症和危重症显著相关。然而，关于先天性心脏病对新冠严重程度影响的研究较少，且仅限于住院患者。本研究旨在探讨合并先天性心脏病患者的新冠病程、严重程度及并发症。
本研究为横断面调查，纳入了在贝鲁特美国大学医学中心儿童心脏中心登记的先天性心脏病患者。调查在儿科心脏病门诊进行，或通过电话远程开展。
共有238名患者参与研究，其中47.9%疑似或确诊感染了SARS-CoV-2。大多数患者病情较轻。症状包括流涕（15.6%）、咳嗽（15.6%）、低热（11.2%）、嗅觉减退（2.7%）、味觉减退（2.5%）、头痛（9.8%）、高热（8.5%）、胃肠道症状（7.6%）、嗜睡（6.3%）、肌肉酸痛（5.6%）、呼吸困难（5.4%）、关节疼痛（4.7%）和寒战（4.7%）。20%的被调查患者需要在家治疗。3.5%的病例需要住院和吸氧治疗，而只有1.5%的患者需要入住重症监护病房。仅出现1例死亡。
先天性心脏病患者的新冠感染表现为轻至中度病程，不一定会增加并发症风险。未发现特定先天性心脏病病变与疾病严重程度之间存在关联。
