非肝硬化门静脉高压症孕妇的母婴结局：一项系统评价和荟萃分析。
Maternal and fetal outcomes in pregnant patients with non-cirrhotic portal hypertension: A systematic review and meta-analysis.
作者信息
Giri Suprabhat, Sahoo Shradhanjali, Sundaram Sridhar, Shukla Akash
机构信息
Department of Gastroenterology, Nizam's Institute of Medical Science, Hyderabad, Telangana, India.
Maternal and Fetal Medicine, Fernandez Hospital, Hyderabad, Telangana, India.
出版信息
Obstet Med. 2023 Sep;16(3):170-177. doi: 10.1177/1753495X221143864. Epub 2023 Jan 17.
BACKGROUND
Concerned studies with respect to the outcome of pregnant patients with non-cirrhotic portal hypertension are limited. Thus, a systematic review and meta-analysis of the available literature was conducted.
METHODS
A literature search was conducted from 1999 to December 2021 for studies evaluating pregnancy outcomes in patients with non-cirrhotic portal hypertension.
RESULTS
Twelve studies were included in the meta-analysis. The pooled rate of variceal bleeding, ascites and severe anemia requiring blood transfusion were 9.6%, 2.3%, and 14.9%, respectively. The pooled rate of spontaneous miscarriage, gestational hypertension, delivery by cesarean section, and postpartum hemorrhage were 11.9%, 4.5%, 36.7%, and 4.7%, respectively. The pooled stillbirth rate was 2.5% and among the live births, the pooled rates of preterm birth, low birth weight, intensive care unit admission, and neonatal mortality were 21.6%, 18.7%, 15.5%, and 1.8%, respectively.
CONCLUSION
Pregnancy in patients with non-cirrhotic portal hypertension is associated with increased maternal & fetal morbidity but mortality remains low.
背景
关于非肝硬化门静脉高压症孕妇结局的相关研究有限。因此，对现有文献进行了系统综述和荟萃分析。
方法
检索了1999年至2021年12月期间评估非肝硬化门静脉高压症患者妊娠结局的研究。
结果
荟萃分析纳入了12项研究。静脉曲张破裂出血、腹水和需要输血的严重贫血的合并发生率分别为9.6%、2.3%和14.9%。自然流产、妊娠期高血压、剖宫产分娩和产后出血的合并发生率分别为11.9%、4.5%、36.7%和4.7%。合并死产率为2.5%，在活产中，早产、低出生体重、入住重症监护病房和新生儿死亡率的合并发生率分别为21.6%、18.7%、15.5%和1.8%。
结论
非肝硬化门静脉高压症患者妊娠与母婴发病率增加相关，但死亡率仍然较低。
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