Caldo-Silva Adriana, Furtado Guilherme E, Chupel Matheus Uba, Letieri Rubens Vinícius, Neves Rafael Santos, Direto Fábio, Barros Marcelo P, Bachi André L L, Matheu Ander, Martins Faber, Massart Alain, Teixeira Ana Maria
Research Centre for Sport and Physical Activity, CIDAF, Faculty of Sport Science and Physical Education, University of Coimbra, Coimbra, Portugal.
Polytechnic Institute of Coimbra, Applied Research Institute, Rua da Misericórdia, Lagar dos Cortiços-S, Martinho do Bispo, Coimbra, Portugal.
Front Sports Act Living. 2023 Aug 30;5:1171220. doi: 10.3389/fspor.2023.1171220. eCollection 2023.
The effectiveness of Branched Chain Amino Acids (BCAAs) supplementation on enhancing exercise performance in both young and older adults remains a topic of debate. Recent research suggests that BCAAs combined with regular exercise might have an impact on human erythropoiesis, blood dynamics, and iron homeostasis. Given the increasing longevity of the global population, it is crucial to investigate the potential benefits of BCAA supplementation and regular exercise as non-pharmacological interventions for improving the overall health of frail older adults. To assess the influence of a 40-week multicomponent exercise intervention (MEP) combined BCCA supplementation on the haematological indicators of frail older adults (83-93 years old) residing in nursing homes. A prospective, naturalistic, controlled clinical trial employing an intervention-washout-intervention was conducted for this purpose. The study included four experimental groups: MEP plus BCAA supplementation (MEP + BCAA, = 8), MEP only ( = 7), BCAA supplementation only ( = 7), and control group non exercising (CG, = 13). Fried's physical frailty (PF) protocol was employed to stratify the participants. Additionally, the assessment included the evaluation of nutritional status, comorbidities, and anthropometric measurements. Among the several haematological markers examined, only mean cellular Haemoglobin Concentration (MCH) [F = 4.09; < 0.03] and Mean Cell haemoglobin Concentration (MCHC) [F = 10, 323; < 0,0001] showed significant effects of time group. Our findings demonstrate that a long-term intervention with BCAA plus MEP did not lead to significant alterations in the haematological profile. An 8-week withdrawal from interventions did not affect the frailty status in the MEP and MEP + BCAA groups, whereas the control group exhibited an increase in PF status. The findings, demonstrating the potential pro-immune effect and maintenance of MCH and MCHC levels, highlight the relevance of incorporating exercise and nutritional strategies to promote healthy aging. This study contributes to the achievement of the United Nations Sustainable Development Goals 3 (good health and well-being) and 10 (reduced Inequalities) for all.
补充支链氨基酸（BCAAs）对提高年轻人和老年人运动表现的有效性仍是一个有争议的话题。最近的研究表明，BCAAs与规律运动相结合可能会对人体红细胞生成、血液动力学和铁稳态产生影响。鉴于全球人口寿命的不断延长，研究补充BCAAs和规律运动作为改善体弱老年人整体健康的非药物干预措施的潜在益处至关重要。为了评估为期40周的多组分运动干预（MEP）联合补充BCCA对居住在养老院的体弱老年人（83 - 93岁）血液学指标的影响。为此进行了一项采用干预-洗脱-干预的前瞻性、自然主义、对照临床试验。该研究包括四个实验组：MEP加BCAA补充组（MEP + BCAA，n = 8）、仅MEP组（n = 7）、仅BCAA补充组（n = 7）和不运动的对照组（CG，n = 13）。采用弗里德身体虚弱（PF）方案对参与者进行分层。此外，评估还包括营养状况、合并症和人体测量学的评估。在所检测的几种血液学标志物中，只有平均红细胞血红蛋白浓度（MCH）[F = 4.09；P < 0.03]和平均红细胞血红蛋白浓度（MCHC）[F = 10,323；P < 0.0001]显示出时间组的显著影响。我们的研究结果表明，长期使用BCAA加MEP干预并未导致血液学特征的显著改变。从干预措施中撤出8周并未影响MEP和MEP + BCAA组的虚弱状态，而对照组的PF状态有所增加。这些结果表明了潜在的促免疫作用以及MCH和MCHC水平的维持，突出了纳入运动和营养策略以促进健康老龄化的相关性。本研究有助于实现联合国针对所有人的可持续发展目标3（良好健康与福祉）和目标10（减少不平等）。
