尿液 L-选择素反映了狼疮肾炎在多民族人群中的临床和组织学肾脏疾病活动和治疗反应。
Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity.
机构信息
Department of Rheumatology, Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Biomedical Engineering, University of Houston, Houston, TX, United States.
出版信息
Front Immunol. 2023 Aug 31;14:1200167. doi: 10.3389/fimmu.2023.1200167. eCollection 2023.
OBJECTIVE
There is an urgent need for novel biomarkers in lupus nephritis (LN). We report a non-invasive urinary biomarker, L-selectin, in two independent multi-ethnic cohorts.
METHODS
uL-selectin was tested cross-sectionally in a Chinese cohort (n=255) and a US cohort (n=219) of SLE patients and controls using ELISA. A longitudinal cohort includes 20 active Chinese LN patients.
RESULTS
uL-selectin was significantly increased in active LN patients compared to active non-renal SLE, inactive LN, inactive non-renal SLE, chronic kidney disease patients, and healthy controls. uL-selectin positively correlated with global and renal disease activities as well as histological activity index and chronicity index (CI). Low uL-selectin was an independent predictor for high CI. During follow-up, uL-selectin levels decreased significantly in the complete renal remission group.
CONCLUSION
uL-selectin is a novel biomarker of disease activity and renal histopathology in LN across multiple ethnicities. It also reflects treatment response in LN patients during follow up.
目的
狼疮肾炎（LN）急需新型生物标志物。我们报告了两个独立的多民族队列中的一种非侵入性尿生物标志物 L-选择素。
方法
使用 ELISA 法在一个中国队列（n=255）和一个美国队列（n=219）的 SLE 患者和对照者中进行横断面检测 uL-选择素。一个纵向队列包括 20 例活动性中国 LN 患者。
结果
与活动性非肾脏 SLE、非活动性 LN、非活动性非肾脏 SLE、慢性肾脏病患者和健康对照者相比，活动性 LN 患者的 uL-选择素显著增加。uL-选择素与全球和肾脏疾病活动以及组织学活动指数和慢性指数（CI）呈正相关。低 uL-选择素是 CI 较高的独立预测因素。在随访期间，完全缓解组的 uL-选择素水平显著下降。
结论
uL-选择素是 LN 多种族疾病活动和肾脏组织病理学的新型生物标志物。它还反映了 LN 患者在随访期间的治疗反应。
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