循环肿瘤DNA作为一种用于癌症诊断的新型且有前景的方法：聚焦于肝细胞癌

Biglari Negin, Soltani-Zangbar Mohammad Sadegh, Mohammadian Jamal, Mehdizadeh Amir, Abbasi Khadijeh

Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.

Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

EXCLI J. 2023 Aug 3;22:752-780. doi: 10.17179/excli2023-6277. eCollection 2023.

Hepatocellular carcinoma (HCC) is one of the most prevalent forms of cancer worldwide. Therefore, it is essential to diagnose and treat HCC patients promptly. As a novel discovery, circulating tumor DNA (ctDNA) can be used to analyze the tumor type and the cancer location. Additionally, ctDNA assists the cancer stage determination, which enables medical professionals to provide patients with the most appropriate treatment. This review will discuss the HCC-related mutated genes diagnosed by ctDNA. In addition, we will introduce the different and the most appropriate ctDNA diagnosis approaches based on the facilities.

肝细胞癌（HCC）是全球最常见的癌症形式之一。因此，及时诊断和治疗HCC患者至关重要。作为一项新发现，循环肿瘤DNA（ctDNA）可用于分析肿瘤类型和癌症位置。此外，ctDNA有助于癌症分期的确定，这使医学专业人员能够为患者提供最合适的治疗。本综述将讨论通过ctDNA诊断的与HCC相关的突变基因。此外，我们将介绍基于现有设备的不同且最合适的ctDNA诊断方法。