噻唑抑制剂与来自……的致病因子溶胞素的分子对接分析。 （原文中“from”后面缺少具体内容）
Molecular docking analysis of thiazo inhibitors with the virulent factor cystalysin from .
作者信息
Andrew Serafina, Sankaran Kavitha, Sekaran Surya, Rengasamy Gayathri, Veeraraghavan Vishnu Priya, Eswaramoorthy Rajalakshmanan
机构信息
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077.
Department of Biomaterials (Green lab), Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai-600077.
出版信息
Bioinformation. 2023 Jan 1;19(1):94-98. doi: 10.6026/97320630019094. eCollection 2023.
has a virulent protein called cystalysin, which causes periodontitis. Therefore, it is of interest to design efficient drug that may have fewer side effects than the present clinical drugs, considering most of them are multidrug resistant. The molecular docking analysis show that the selected thiazo derivatives (1-6) show better binding energies and amino acid interactions compared to the clinically proven drugs proving to be potential inhibitors against the protein.
它有一种名为溶胞素的毒性蛋白，可导致牙周炎。因此，考虑到目前大多数临床药物都具有多重耐药性，设计出比现有临床药物副作用更少的高效药物是很有意义的。分子对接分析表明，与经临床验证的药物相比，所选的噻唑衍生物（1-6）显示出更好的结合能和氨基酸相互作用，证明它们是该蛋白的潜在抑制剂。
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