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对接受不间断低剂量阿司匹林治疗的患者拔牙后术后出血延长发生率的评估,以及评估拔牙前停用此类药物的必要性。

An Assessment of the Incidence of Prolonged Postoperative Bleeding After Dental Extraction Among Patients on Uninterrupted Low Dose Aspirin Therapy and to Evaluate the Need to Stop Such Medication Prior to Dental Extractions.

作者信息

Eapen Brigit V, Baig M F, Avinash S

机构信息

Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha University, Chennai, 600077 India.

出版信息

J Maxillofac Oral Surg. 2017 Mar;16(1):48-52. doi: 10.1007/s12663-016-0912-8. Epub 2016 Jun 17.

Abstract

PURPOSE

To propose that low dose aspirin therapy need not be withdrawn for routine dental extraction procedure.

AIM

This study was designed to evaluate the post operative bleeding in patients on low dose aspirin therapy by dividing them into two groups: one with withdrawing and the other without withdrawing the regime before dental extraction.

MATERIALS AND METHODS

This study included 80 patients on low dose aspirin therapy. They were divided into two groups of 40 patients each; Group I (control group) included patients on who were asked to stop the medication 5 days prior to dental extraction; Group II (test group) included patients who were asked not to stop the medication prior to dental extraction. Strict atraumatic extractions were performed by a single surgeon. Data were analyzed using the independent "" test @ 80 % power.

RESULTS

The mean pre-operative bleeding time in the control group was 87.75 s and the test group was 95.75 s which was statistically significant ( < 0.05). The mean pre-operative clotting time in the control group was 228.63 s and the test group was 246.25 s which was also statistically significant ( < 0.05). No patients in either group had any episode of prolonged postoperative bleeding following extraction from the surgical site and no local haemostatic measures had to be used except for one patient in Group II.

CONCLUSION

Authors conclude from this study that dental extraction procedures in patients on low-dose therapy can be safely carried out without stopping the antiplatelet therapy.

摘要

目的

提出低剂量阿司匹林治疗无需因常规拔牙手术而停药。

目的

本研究旨在通过将低剂量阿司匹林治疗的患者分为两组来评估术后出血情况:一组在拔牙前停药,另一组在拔牙前不停药。

材料与方法

本研究纳入80例接受低剂量阿司匹林治疗的患者。他们被分为两组,每组40例;第一组(对照组)包括在拔牙前5天被要求停药的患者;第二组(试验组)包括在拔牙前不被要求停药的患者。由一名外科医生进行严格的无创拔牙。使用独立t检验(检验效能为80%)对数据进行分析。

结果

对照组术前平均出血时间为87.75秒,试验组为95.75秒,具有统计学意义(P<0.05)。对照组术前平均凝血时间为228.63秒,试验组为246.25秒,也具有统计学意义(P<0.05)。两组患者术后均无手术部位长时间出血的情况,除第二组有1例患者外,均无需采取局部止血措施。

结论

作者从本研究得出结论,低剂量治疗患者的拔牙手术可以在不停用抗血小板治疗的情况下安全进行。

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