Vadhva P, Hasan M
J Environ Sci Health B. 1986 Oct;21(5):413-24. doi: 10.1080/03601238609372534.
The effect of dichlorvos (DDVP) (0-0, dimethyl 2:2-dichlorovinyl phosphate), on various lipid fractions and lipid peroxidation in the discrete areas of the brain and spinal cord were studied in the fresh water teleost (Heteropneustes fossilis). Fishes were exposed to three different doses (3.0, 6.0 and 9.0 ppm) of DDVP daily for 7 days. Dose-related increase in the levels of total lipids, cholesterol and esterified fatty acids was detected in the fore brain, optic lobes, cerebellum, medulla oblongata and spinal cord. However, phospholipids were significantly decreased in the aforementioned regions of the central nervous system. The rate of lipid peroxidation was significantly increased in all the regions of the CNS.
研究了敌敌畏（DDVP，0,0-二甲基-2,2-二氯乙烯基磷酸酯）对淡水硬骨鱼（印度胡鲶）脑和脊髓不同区域各种脂质组分及脂质过氧化的影响。将鱼每天暴露于三种不同剂量（3.0、6.0和9.0 ppm）的敌敌畏中，持续7天。在前脑、视叶、小脑、延髓和脊髓中检测到总脂质、胆固醇和酯化脂肪酸水平呈剂量相关增加。然而，在中枢神经系统的上述区域中磷脂显著减少。中枢神经系统所有区域的脂质过氧化速率均显著增加。
