Haider S S, Hasan M, Hasan S N, Khan S R, Ali S F
Neurotoxicology. 1981 Nov;2(3):443-50.
Experiments to evaluate the neurochemical action of gaseous pollutants were performed in a specifically designed inhalation chamber. Exposure of guinea pigs to 10 ppm of SO2 for one hour daily for 21 days produced a significant depletion of total lipids and free fatty acids in all brain regions. Phospholipid and cholesterol content of the cerebellum and brain stem were also decreased, but were increased in cerebral hemisphere. Esterified fatty acids were depleted in the cerebral hemisphere and brain stem, but exhibited increment in the cerebellum. The rate of lipid peroxidation and the activity of lipase were increased significantly in all the regions of the brain. The results clearly indicate that SO2-exposure induces degradation of brain lipids. Interestingly, the lipid contents are affected differentially in the various parts of the brain.
在一个专门设计的吸入舱中进行了评估气态污染物神经化学作用的实验。将豚鼠每天暴露于10 ppm的二氧化硫中，持续21天，每天暴露1小时，结果显示所有脑区的总脂质和游离脂肪酸显著减少。小脑和脑干的磷脂和胆固醇含量也降低了，但大脑半球中的含量增加了。大脑半球和脑干中的酯化脂肪酸减少，但小脑中的酯化脂肪酸含量增加。大脑所有区域的脂质过氧化速率和脂肪酶活性均显著增加。结果清楚地表明，接触二氧化硫会导致脑脂质降解。有趣的是，大脑不同部位的脂质含量受到的影响不同。
