Knewitz Daniel, Almerey Tariq, Gabriel Emmanuel
Mayo Clinic, Jacksonville, FL, USA.
Department of Surgical Oncology, Mayo Clinic, Jacksonville, FL, USA.
J Gastrointest Oncol. 2023 Aug 31;14(4):1849-1855. doi: 10.21037/jgo-23-159. Epub 2023 Jul 5.
Accurate cancer prognostication allows for conscious decision-making. There is a need for precise indices, along with predictive biomarkers, which aid cancer prognostication. We sought to conduct an overview of the current state of prognostic indices and biomarkers in the evaluation of gastrointestinal (GI) cancers, specifically esophageal, colon and rectal.
We conducted a comprehensive review of articles in the PubMed database between September 2001 and February 2022. Only articles written in English were included. We reviewed retrospective analyses and prospective observational studies.
Nomograms are well-described tools that provide estimates of specific cancer-related events, such as overall survival (OS). They are also useful in unroofing specific patient-related variables, which may be associated with cancer survival. Certain prognostic indices have been tested against each other with the goal of discerning superiority. Finally, specific biomarkers have emerged as promising prognostic indicators.
Nomograms play a significant role in the prognostication of GI cancer. The identification of specific biomarkers in cancer prognostication is evolving. As we embark on the era of precision medicine, further investigation of reliable prognostic indices and biomarkers is needed.
准确的癌症预后评估有助于做出明智的决策。除了预测性生物标志物外，还需要精确的指标来辅助癌症预后评估。我们旨在对胃肠道（GI）癌症，特别是食管癌、结肠癌和直肠癌评估中预后指标和生物标志物的现状进行综述。
我们对2001年9月至2022年2月期间PubMed数据库中的文章进行了全面回顾。仅纳入英文撰写的文章。我们回顾了回顾性分析和前瞻性观察性研究。
列线图是一种描述详尽的工具，可提供对特定癌症相关事件（如总生存期（OS））的估计。它们还有助于揭示可能与癌症生存相关的特定患者相关变量。为了辨别优越性，某些预后指标已相互进行了测试。最后，特定的生物标志物已成为有前景的预后指标。
列线图在胃肠道癌症的预后评估中发挥着重要作用。癌症预后评估中特定生物标志物的识别正在不断发展。随着我们迈入精准医学时代，需要进一步研究可靠的预后指标和生物标志物。
