Zhang Ke, Chen Yuan, Zhu Jie, Ge Xinyu, Wu Junqing, Xu Peng, Yao Jie
Dalian Medical University, Dalian, China.
Medical College of Yangzhou University, Yangzhou, China.
Front Med (Lausanne). 2023 Aug 31;10:1213136. doi: 10.3389/fmed.2023.1213136. eCollection 2023.
Single-cell sequencing is a high-throughput technique that enables detection of genomic, transcriptomic, and epigenomic information at the individual cell level, offering significant advantages in detecting cellular heterogeneity, precise cell classification, and identifying rare subpopulations. The technique holds tremendous potential in improving the diagnosis and treatment of pancreatic cancer. Moreover, single-cell sequencing provides unique insights into the mechanisms of pancreatic cancer metastasis and cachexia, paving the way for developing novel preventive strategies. Overall, single-cell sequencing has immense potential in promoting early diagnosis, guiding personalized treatment, and preventing complications of pancreatic cancer. Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment.
单细胞测序是一种高通量技术，能够在单个细胞水平上检测基因组、转录组和表观基因组信息，在检测细胞异质性、精确细胞分类以及识别罕见亚群方面具有显著优势。该技术在改善胰腺癌的诊断和治疗方面具有巨大潜力。此外，单细胞测序为胰腺癌转移和恶病质的机制提供了独特见解，为制定新的预防策略铺平了道路。总体而言，单细胞测序在促进胰腺癌的早期诊断、指导个性化治疗以及预防并发症方面具有巨大潜力。新兴的单细胞测序技术无疑将增进我们对胰腺癌复杂生物学的理解，并为其临床诊断和治疗的新方向铺平道路。
