Synthesis of some new isoxazole compounds and their biological tyrosinase and antioxidant activities.

In this study, 7 new isoxazole compounds () were synthesized from the cyclization of chalcone compounds () containing different functional groups with hydroxylamine hydrochloride in alkaline medium. Tyrosinase and antioxidant properties of were investigated. IC values for the tyrosinase enzyme inhibition of compounds , , , and were varied between 61.47 ± 3.46 and 188.52 ± 5.85, while compounds , and did not show any inhibition effect. The antioxidant properties of were investigated by DPPH and CUPRAC methods. Compound showed the best DPPH radical scavenging activity (SC: 40.21 ± 2.71), while and had shown the greatest Cupric ion reducing effect as 1.233 ± 0.015 and 1.245 ± 0.019 mg TEAC/mg, respectively. As a result, the change of functional groups in the synthesized compounds caused a significant difference in the biological properties of .