异恶唑在药物化学中的最新进展。

The recent progress of isoxazole in medicinal chemistry.

机构信息

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China.

Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing 210023, China.

出版信息

Bioorg Med Chem. 2018 Jul 23;26(12):3065-3075. doi: 10.1016/j.bmc.2018.05.013. Epub 2018 May 28.

DOI:10.1016/j.bmc.2018.05.013

PMID:29853341

Abstract

Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities. Developing compounds with heterocycle rings has been one of the trends. The integration of isoxazole ring can offer improved physical-chemical properties. Because of the unique profiles, isoxazole ring becomes a popular moiety in compounds design. In this review article, the major focus has been paid to the applications of isoxazole compounds in treating multiple diseases, including anticancer, antimicrobial, anti-inflammatory, etc. Strategies for compounds design for preclinical, clinical, and FDA approved drugs were discussed. Also, the emphasis has been addressed to the future perspectives and trend for the application.

摘要

异恶唑类化合物具有广泛的靶标和广泛的生物活性。开发具有杂环的化合物一直是趋势之一。异恶唑环的集成可以提供改善的物理化学性质。由于独特的特性，异恶唑环成为化合物设计中的热门部分。在这篇综述文章中，主要关注异恶唑化合物在治疗多种疾病（包括抗癌、抗菌、抗炎等）中的应用。讨论了用于临床前、临床和 FDA 批准药物的化合物设计策略。还强调了未来的应用前景和趋势。