强化证据：在斯威士兰的医院出生监测中，无论产妇的艾滋病毒感染状况和多替拉韦暴露情况如何，神经管缺陷的发生率相似。
Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini.
作者信息
Gill Michelle M, Khumalo Philisiwe, Chouraya Caspian, Kunene Mthokozisi, Dlamini Futhi, Hoffman Heather J, Scheuerle Angela E, Nhlabatsi Bonisile, Mngometulu Wiseman, Dlamini-Madlopha Ntombikayise, Mthunzi Nompumelelo, Mofenson Lynne
机构信息
Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA.
Elizabeth Glaser Pediatric AIDS Foundation, Mbabane, Eswatini.
出版信息
Open Forum Infect Dis. 2023 Aug 18;10(9):ofad441. doi: 10.1093/ofid/ofad441. eCollection 2023 Sep.
Birth defect surveillance in Eswatini in 2020-2021 identified 0.80% defects (197/24 599 live and stillborn infants). Neural tube defect (NTD) prevalence was 0.08%, 0.08%, and 0.15% for 4902 women on dolutegravir preconception, 17 285 HIV-negative women, and 1320 women on efavirenz preconception, respectively, more definitively refuting the dolutegravir preconception NTD safety signal.
2020 - 2021年斯威士兰的出生缺陷监测发现缺陷率为0.80%（24599例活产和死产婴儿中有197例）。神经管缺陷（NTD）的患病率在孕前服用多替拉韦的4902名妇女中为0.08%，在17285名HIV阴性妇女中为0.08%，在孕前服用依非韦伦的1320名妇女中为0.15%，这更明确地驳斥了孕前服用多替拉韦的神经管缺陷安全信号。
Zotero 插件