Tadge Tejaswini, Garje Sonali, Saxena Varun, Raichur Ashok M
Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India.
ACS Omega. 2023 Sep 1;8(36):32294-32310. doi: 10.1021/acsomega.3c04569. eCollection 2023 Sep 12.
Shape memory-assisted self-healing polymers have drawn attention over the past few years owing to their interdisciplinary and wide range of applications. Self-healing and shape memory are two approaches used to improve the applicability of polymers in the biomedical field. Combining both these approaches in a polymer composite opens new possibilities for its use in biomedical applications, such as the "close then heal" concept, which uses the shape memory capabilities of polymers to bring injured sections together to promote autonomous healing. This review focuses on using shape memory-assisted self-healing approaches along with their respective affecting factors for biomedical applications such as tissue engineering, drug delivery, biomaterial-inks, and 4D printed scaffolds, soft actuators, wearable electronics, etc. In addition, quantification of self-healing and shape memory efficiency is also discussed. The challenges and prospects of these polymers for biomedical applications have been summarized.
在过去几年中，形状记忆辅助自修复聚合物因其跨学科性质和广泛的应用而备受关注。自修复和形状记忆是提高聚合物在生物医学领域适用性的两种方法。在聚合物复合材料中结合这两种方法为其在生物医学应用中的使用开辟了新的可能性，例如“先闭合再愈合”概念，该概念利用聚合物的形状记忆能力将受伤部位聚集在一起以促进自主愈合。本综述重点关注形状记忆辅助自修复方法及其各自的影响因素在生物医学应用中的应用，如组织工程、药物递送、生物材料墨水和4D打印支架、软致动器、可穿戴电子产品等。此外，还讨论了自修复和形状记忆效率的量化。总结了这些聚合物在生物医学应用中的挑战和前景。
