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Novel insights in phosphodiesterase 4 subtype inhibition to target neuroinflammation and stimulate remyelination.

作者信息

Schepers Melissa, Vanmierlo Tim

机构信息

Department of Neuroscience, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands; University MS Center (UMSC) Hasselt - Pelt, Hasselt, Belgium.

出版信息

Neural Regen Res. 2024 Mar;19(3):493-494. doi: 10.4103/1673-5374.380899.

DOI:10.4103/1673-5374.380899
PMID:37721269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10581562/
Abstract
摘要

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Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model.在三维再生模型中，磷酸二酯酶（PDE）4抑制可促进雪旺细胞髓鞘形成。
Eur J Pharm Sci. 2023 Jun 1;185:106441. doi: 10.1016/j.ejps.2023.106441. Epub 2023 Mar 31.
2
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.选择性磷酸二酯酶4（PDE4）亚型抑制为干预多发性硬化症的神经炎症与髓鞘损伤特征提供了新机会。
Brain Behav Immun. 2023 Mar;109:1-22. doi: 10.1016/j.bbi.2022.12.020. Epub 2022 Dec 28.
3
The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors.磷酸二酯酶 4 酶作为药理学靶点的分子生物学：同工型、构象状态和抑制剂的相互作用。
Pharmacol Rev. 2021 Jul;73(3):1016-1049. doi: 10.1124/pharmrev.120.000273.
4
PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.PANC-1 细胞选择性抑制环腺苷酸磷酸二酯酶 4（PDE4）可诱导小鼠胃轻瘫。
FASEB J. 2020 Sep;34(9):12533-12548. doi: 10.1096/fj.202001016RR. Epub 2020 Aug 1.
5
Advances in the Development of Phosphodiesterase-4 Inhibitors.磷酸二酯酶-4 抑制剂的研究进展。
J Med Chem. 2020 Oct 8;63(19):10594-10617. doi: 10.1021/acs.jmedchem.9b02170. Epub 2020 Jun 10.
6
Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment.靶向磷酸二酯酶——多发性硬化症治疗的个体化方法。
Front Immunol. 2019 Jul 24;10:1727. doi: 10.3389/fimmu.2019.01727. eCollection 2019.
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Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond.治疗性靶向 3'，5'-环核苷酸磷酸二酯酶：抑制与超越。
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