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描述哥伦比亚波哥大两家重症监护病房患者气管内导管定植的真菌菌群。

Description of the colonizing mycobiota of endotracheal tubes from patients admitted to two intensive care units in Bogotá, Colombia.

机构信息

Genética Molecular, Corporación CorpoGen, Bogotá, D.C., Colombia; Escuela de Medicina, Universidad Pedagógica y Tecnológica de Colombia, Tunja, Colombia.

Departamento de Patología y Laboratorios, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, D.C., Colombia.

出版信息

Biomedica. 2023 Aug 31;43(Sp. 1):181-193. doi: 10.7705/biomedica.6884.

DOI:10.7705/biomedica.6884
PMID:37721909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10586799/
Abstract

Introduction. Medical device colonization by pathogenic microorganisms is a risk factor for increasing infections associated with health care and, consequently, the morbidity and mortality of intubated patients. In Colombia, fungal colonization of endotracheal tubes has not been described, and this information could lead to new therapeutic options for the benefit of patients. Objective. To describe the colonizing fungi of the endotracheal tubes from patients in the intensive care unit, along with its antifungal sensitivity profile. Materials and methods. We conducted a descriptive, observational study in two health centers for 12 months. Endotracheal tubes were collected from patients in intensive care units. Samples were processed for culture, fungi identification, and antifungal sensitivity profile assessment. Results. A total of 121 endotracheal tubes, obtained from 113 patients, were analyzed: 41.32 % of the tubes were colonized by Candida albicans (64.62%), C. non‑albicans (30.77%), Cryptococcus spp. (3.08%) or molds (1.54%). All fungi evaluated showed a high sensitivity to antifungals, with a mean of 91%. Conclusion. Fungal colonization was found in the endotracheal tubes of patients under invasive mechanical ventilation. The antifungal sensitivity profile in these patients was favorable. A clinical study is required to find possible correlations between the colonizing microorganisms and infectivity.

摘要

引言。与医疗保健相关的感染与致病性微生物对医疗设备的定殖有关,这是增加发病率和死亡率的风险因素。在哥伦比亚,尚未描述过气管内导管的真菌感染情况,这些信息可能为患者带来新的治疗选择。目的。描述重症监护病房患者的气管内导管定殖真菌及其抗真菌药敏谱。材料与方法。我们在两个医疗中心进行了为期 12 个月的描述性观察性研究。从重症监护病房的患者中采集气管内导管样本。对样本进行培养、真菌鉴定和抗真菌药敏谱评估。结果。共分析了 113 例患者的 121 个气管内导管:64.62%(41.32%)的导管被白色念珠菌(Candida albicans)、非白念珠菌(Candida non-albicans)、隐球菌(Cryptococcus spp.)或霉菌(Molds)定殖。所有评估的真菌对各种抗真菌药物均表现出高度敏感性,平均敏感性为 91%。结论。在接受有创机械通气的患者的气管内导管中发现了真菌感染。这些患者的抗真菌药敏谱较好。需要进行临床研究以寻找定殖微生物与感染之间的可能相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e0/10586799/18965ebc3103/2590-7379-bio-43-s1-6884-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e0/10586799/18965ebc3103/2590-7379-bio-43-s1-6884-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65e0/10586799/18965ebc3103/2590-7379-bio-43-s1-6884-gf1.jpg

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Endotracheal tube microbiome in hospitalized patients defined largely by hospital environment.住院患者的气管内管微生物组主要由医院环境决定。
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