Jeong Woo Kyoung
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Center for Imaging Sciences, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Liver Cancer. 2023 Sep;23(2):272-283. doi: 10.17998/jlc.2023.08.25. Epub 2023 Sep 19.
Sonazoid contrast-enhanced ultrasonography (CEUS) is a promising technique for the detection and diagnosis of focal liver lesions, particularly hepatocellular carcinoma (HCC). Recently, a collaborative effort between the Korean Society of Radiology and Korean Society of Abdominal Radiology resulted in the publication of guidelines for diagnosing HCC using Sonazoid CEUS. These guidelines propose specific criteria for identifying HCC based on the imaging characteristics observed during Sonazoid CEUS. The suggested diagnostic criteria include nonrim arterial phase hyperenhancement, and the presence of late and mild washout, or Kupffer phase washout under the premise that the early or marked washout should not occur during the portal venous phase. These criteria aim to improve the accuracy of HCC diagnosis using Sonazoid CEUS. This review offers a comprehensive overview of Sonazoid CEUS in the context of HCC diagnosis. It covers the fundamental principles of Sonazoid CEUS and its clinical applications, and introduces the recently published guidelines. By providing a summary of this emerging technique, this review contributes to a better understanding of the potential role of Sonazoid CEUS for diagnosing HCC.
舒血管素增强超声造影（CEUS）是一种用于检测和诊断肝脏局灶性病变，尤其是肝细胞癌（HCC）的有前景的技术。最近，韩国放射学会和韩国腹部放射学会共同努力，发表了使用舒血管素CEUS诊断HCC的指南。这些指南根据舒血管素CEUS观察到的影像特征，提出了识别HCC的具体标准。建议的诊断标准包括非边缘动脉期高增强，以及在门静脉期不应出现早期或明显消退的前提下，存在晚期轻度消退或库普弗细胞期消退。这些标准旨在提高使用舒血管素CEUS诊断HCC的准确性。本综述全面概述了舒血管素CEUS在HCC诊断中的应用。它涵盖了舒血管素CEUS的基本原理及其临床应用，并介绍了最近发表的指南。通过总结这种新兴技术，本综述有助于更好地理解舒血管素CEUS在诊断HCC中的潜在作用。
