Department of Medicine, Hospital Sibu, KM 5 1/2, Jalan Ulu Oya, 96000 Sibu, Sarawak, Malaysia.
Acta Neurol Taiwan. 2023 Dec 30;32(4):207-211.
Guillain-Barré Syndrome (GBS) associated with SARS-CoV-2 vaccine administration is very rare. Early recognition of GBS at early stage could prevent extensive nerve damage with potential respiratory and autonomic failure.
We report a case of paraparetic spectrum of GBS in a 53-year-old lady who presented with rapidly progressive acute flaccid paralysis involving both lower extremities with areflexia eight days after the first dose of Sinovac vaccine for SARS-CoV-2 in Malaysia. Cerebrospinal fluid (CSF) albuminocytological dissociation was seen and nerve conduction study (NCS) revealed sensory neuropathy. The diagnosis of GBS was made based on the Brighton criteria. Patient responded well to intravenous immunoglobulin (IVIG).
Though there is currently no convincing evidence of any causation between GBS and SARS- CoV-2 vaccination, clinicians should remain vigilant and consider GBS in the differential diagnosis for patient who presents with weakness with reduced or absent deep tendon reflex after vaccination against SARS-CoV-2.
与 SARS-CoV-2 疫苗接种相关的格林-巴利综合征（GBS）非常罕见。早期识别 GBS 可以防止广泛的神经损伤，避免潜在的呼吸和自主功能衰竭。
我们报告了一例 53 岁女性的类 GB 综合征病例，她在马来西亚接种首剂科兴 SARS-CoV-2 疫苗后 8 天出现快速进展性急性弛缓性瘫痪，累及双下肢，且反射消失。脑脊液（CSF）蛋白细胞分离现象明显，神经传导研究（NCS）显示感觉性神经病。根据布赖顿标准诊断为 GBS。患者对静脉注射免疫球蛋白（IVIG）反应良好。
虽然目前尚无令人信服的证据表明 GBS 与 SARS-CoV-2 疫苗接种之间存在因果关系，但临床医生仍应保持警惕，并在考虑接种 SARS-CoV-2 疫苗后出现无力且深部腱反射减弱或消失的患者的鉴别诊断中考虑 GBS。
