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mRNA COVID-19 疫苗接种后出现感觉运动性共济失调型吉兰-巴雷综合征伴味觉障碍

Sensory Ataxic Guillain-Barré Syndrome with Dysgeusia after mRNA COVID-19 Vaccination.

机构信息

Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Japan.

Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Japan.

出版信息

Intern Med. 2022 Jun 1;61(11):1757-1760. doi: 10.2169/internalmedicine.8967-21. Epub 2022 Mar 26.

Abstract

Guillain-Barré syndrome (GBS) has occasionally occurred in people who have received coronavirus disease 2019 (COVID-19) vaccines. Dysgeusia is rare symptom of GBS. We herein report a rare case of sensory ataxic GBS with dysgeusia just after the second dose of the Pfizer-BioNTech COVID-19 vaccine. Although autoantibodies against glycolipids were not detected, immunotherapy with intravenous immunoglobulin and methylprednisolone pulse therapy effectively ameliorated the symptoms. Our report suggests that the COVID-19 vaccine may induce various clinical subtypes of GBS, including a rare variant with sensory ataxia and dysgeusia.

摘要

吉兰-巴雷综合征(GBS)偶尔会发生在接种过 2019 冠状病毒病(COVID-19)疫苗的人群中。味觉障碍是 GBS 的罕见症状。本文报告了首例在接种辉瑞-生物科技公司(Pfizer-BioNTech)COVID-19 疫苗第二剂后出现味觉障碍的感觉运动性共济失调型 GBS 病例。尽管未检测到针对神经节苷脂的自身抗体,但免疫球蛋白静脉滴注和甲基强的松龙冲击疗法的免疫治疗有效改善了症状。我们的报告表明,COVID-19 疫苗可能会诱发 GBS 的各种临床亚型,包括一种伴有感觉运动性共济失调和味觉障碍的罕见变异型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3bc/9259306/ee9510f1d34c/1349-7235-61-1757-g001.jpg

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