Programa de Pós-Graduação em Imunologia Básica e Aplicada, Instituto de Ciências Biológicas, Universidade Federal do Amazonas (UFAM), Manaus, Brazil; Diretoria de Ensino e Pesquisa, Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, Brazil.
Diretoria de Ensino e Pesquisa, Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, Brazil.
Cytokine. 2023 Nov;171:156371. doi: 10.1016/j.cyto.2023.156371. Epub 2023 Sep 17.
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the world, and accounts for 25% of all childhood cancers among children under 15 years of age. Longitudinal studies have shown that children with ALL are born with a deregulated immune response that, together with postnatal environmental exposures, favor the onset of the disease. In this context, IL-10, a key cytokine in the regulation of the immune response, presents itself as a paradoxical mediator, initially influencing the development of ALL through the regulation of inflammatory processes and later on the progression of malignancy, with the increase of this molecule in the leukemia microenvironment. According to the literature, this cytokine plays a critical role in the natural history of the disease and plays an important role in two different though complex scenarios. Thus, in this review, we explore the dual role of IL-10 in ALL, and describe its biological characteristics, immunological mechanisms and genetics, as well as its impact on the leukemia microenvironment and its clinical implications.
急性淋巴细胞白血病（ALL）是世界上最常见的儿科癌症，占所有 15 岁以下儿童癌症的 25%。纵向研究表明，ALL 患儿天生免疫反应失调，加上出生后的环境暴露，有利于疾病的发生。在这种情况下，白细胞介素 10（IL-10）作为免疫反应调节的关键细胞因子，表现为一种矛盾的介质，最初通过调节炎症过程影响 ALL 的发展，随后随着白血病微环境中该分子的增加，影响恶性肿瘤的进展。根据文献，这种细胞因子在疾病的自然史中起着关键作用，并在两个不同但复杂的情况下发挥重要作用。因此，在这篇综述中，我们探讨了 IL-10 在 ALL 中的双重作用，并描述了其生物学特征、免疫学机制和遗传学，以及其对白血病微环境的影响及其临床意义。
