Department of Cardiothoracic Surgery, Huashan Hospital of Fudan University, Shanghai, China.
Department of Cardiothoracic Surgery, Huashan Hospital of Fudan University, Shanghai, China.
Exp Cell Res. 2023 Nov 1;432(1):113763. doi: 10.1016/j.yexcr.2023.113763. Epub 2023 Sep 17.
Aerobic cellular respiration requires oxygen, which is an essential part of cardiomyocyte metabolism. Thus, oxygen is required for the physiologic metabolic activities and development of adult hearts. However, the activities of metabolic pathways associated with hypoxia in cardiomyocytes (CMs) have not been conclusively described. In this review, we discuss the role of hypoxia in the development of the hearts metabolic system, and the metabolic remodeling associated with the hypoxic adult heart. Hypoxia-inducible factors (HIFs), the signature transcription factors in hypoxic environments, is also investigated for their potential to modulate hypoxia-induced metabolic changes. Metabolic remodeling existing in hypoxic hearts have also been shown to occur in chronic failing hearts, implying that novel therapeutic options for heart failure (HF) may exist from the hypoxic perspective. The pressure overload-induced HF and diabetes-induced HF are also discussed to demonstrate the effects of HIF factor-related pathways to control the metabolic remodeling of failing hearts.
需氧细胞呼吸需要氧气，这是心肌细胞代谢的重要组成部分。因此，氧气是成年心脏的生理代谢活动和发育所必需的。然而，与心肌细胞（CMs）缺氧相关的代谢途径的活性尚未得到明确描述。在这篇综述中，我们讨论了缺氧在心脏代谢系统发育中的作用，以及与缺氧成年心脏相关的代谢重塑。还研究了缺氧诱导因子（HIFs）作为缺氧环境中的标志性转录因子，以探讨其调节缺氧诱导代谢变化的潜力。缺氧心脏中存在的代谢重塑也存在于慢性衰竭心脏中，这意味着从缺氧角度来看，可能存在心力衰竭（HF）的新治疗选择。还讨论了压力超负荷诱导的 HF 和糖尿病诱导的 HF，以证明与 HIF 因子相关的途径对控制衰竭心脏代谢重塑的影响。
