睡眠-夜间的慢波活动可以预测左旋多巴诱导的运动障碍。

Slow wave activity across sleep-night could predict levodopa-induced dyskinesia.

机构信息

Parkinson Disease and Movement Disorder Center, Neurocenter of Southern Switzerland, EOC, Via Tesserete 46, 6903, Lugano, Switzerland.

Faculty of Biomedical Sciences, Università Della Svizzera Italiana (USI), Via Giuseppe Buffi 13, Lugano, Switzerland.

出版信息

Sci Rep. 2023 Sep 19;13(1):15468. doi: 10.1038/s41598-023-42604-1.

DOI:10.1038/s41598-023-42604-1

PMID:37726375

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10509191/

Abstract

A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID). To corroborate the role of SWA in LID development, 15 PD patients with LID, who underwent a polysomnography before LID's appearance, were included. Slow wave sleep epochs were extracted, combined and segmented into early and late sleep. SWA power was calculated. A linear regression model established that the SWA overnight decrease could predict the time to the emergence of LID. Our finding supports the link between SWA-mediated synaptic downscaling and the development of LID. If confirmed, it could pave the way to the study of possible sleep targeted therapies able to protect PD patients from LID development.

摘要

帕金森病（PD）伴左旋多巴诱导运动障碍（LID）患者存在慢波活动（SWA）介导的突触下调过程中断。为了证实 SWA 在 LID 发展中的作用，纳入了 15 名出现 LID 前接受过多导睡眠图检查的 PD 伴 LID 患者。提取慢波睡眠期，合并并分段为早期和晚期睡眠。计算 SWA 功率。建立线性回归模型表明，SWA 夜间减少可以预测 LID 出现的时间。我们的发现支持 SWA 介导的突触下调与 LID 发展之间的联系。如果得到证实，它可能为研究可能针对睡眠的靶向治疗铺平道路，以保护 PD 患者免受 LID 发展的影响。