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[左心室功能不全时的心肌血运重建]

[Myocardial revascularization in left ventricular dysfunction].

作者信息

Godoy-Palomino Armando L

机构信息

Instituto Nacional Cardiovascular INCOR, Servicio de Cardiología no Invasiva.

Universidad Nacional Mayor de San Marcos Universidad Nacional Mayor de San Marcos Universidad Nacional Mayor de San Marcos Peru.

出版信息

Arch Peru Cardiol Cir Cardiovasc. 2021 Mar 31;2(1):40-48. doi: 10.47487/apcyccv.v2i1.112. eCollection 2021 Jan-Mar.

Abstract

Left ventricular dysfunction due to adverse remodeling constitutes the underlying structural anatomical condition of heart failure and is the main and most severe sequela of long-term coronary artery disease, and it is the only pathology that can benefit from surgical myocardial revascularization. For its control, there are current medical treatment guidelines supported by the favorable results of contemporary clinical trials. However, in recent studies, there was no benefit of surgical revascularization in addition to optimal medical therapy when compared to optimal medical therapy alone. The identification of myocardial viability to guide revascularization was also not favorable. The results of the extension of these trials showed benefit of revascularization treatment, but the detection of viability remained unfavorable. Increased left ventricular ejection fraction, as a marker of benefit from revascularization, was not associated with lower mortality. There are many reasons why the known advantages of revascularization were not identified. Despite this discrepancies, myocardial revascularization and the identification of viability in these patients are supported and are usually indications for routine treatment.

摘要

由于不良重塑导致的左心室功能障碍构成了心力衰竭的潜在结构解剖学状况,是长期冠状动脉疾病的主要且最严重的后遗症,并且是唯一能从外科心肌血运重建中获益的病理情况。对于其控制,有当代临床试验的良好结果所支持的现行医学治疗指南。然而,在最近的研究中,与单纯的最佳药物治疗相比,在最佳药物治疗基础上进行外科血运重建并无益处。用于指导血运重建的心肌存活能力的识别也不理想。这些试验扩展的结果显示血运重建治疗有益,但存活能力的检测仍然不理想。作为血运重建获益标志的左心室射血分数增加与较低死亡率无关。血运重建的已知优势未被识别有很多原因。尽管存在这些差异,但这些患者的心肌血运重建和存活能力的识别仍得到支持,并且通常是常规治疗的指征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3ea/10506559/0a5df11b7ddc/apcyccv-2-40-g001.jpg

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