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阿片类药物和酒精联合使用预防研究(COAPS)。

Co-use of Opioid Medications and Alcohol Prevention Study (COAPS).

机构信息

University of Tennessee Health Sciences Center, Nashville, TN, USA.

Department of Psychology, University of Texas, El Paso, TX, USA.

出版信息

Subst Abus. 2023 Jul;44(3):130-135. doi: 10.1177/08897077231191840. Epub 2023 Sep 20.

Abstract

While there is limited research in the field regarding the various dimensions of co-use of alcohol and opioid medication, particularly related to co-use and levels of severity, our research has shown 20% to 30% of community pharmacy patients receiving opioid pain medications are engaged in co-use. Co-use of alcohol and opioid medications is a significant risk factor for opioid-related overdose. Community pharmacy is a valuable yet underutilized resource and setting for addressing the US opioid epidemic, with an untapped potential for identification of and intervention for risks associated with co-use of alcohol and opioids. This commentary describing the "Co-use of Opioid Medications and Alcohol Prevention Study (COAPS)" offers an innovative and promising approach to mitigating serious risks associated with co-use of alcohol (risk and non-risk use) and opioids in community pharmacy. COAPS aim 1involves adapting an existing opioid misuse intervention to target co-use of alcohol and opioid mediations. COAPS aim 2 involves testing the adapted intervention within a small-scale pilot randomized controlled trial (N = 40) to examine feasibility, acceptability and preliminary efficacy of the intervention versus standard care. COAPS aim 3 involves conducting key informant interviews related to future implementation of larger scale studies or service delivery in community pharmacy settings.

摘要

虽然在酒精和阿片类药物共同使用的各个方面,特别是在共同使用和严重程度方面,该领域的研究有限,但我们的研究表明,接受阿片类止痛药的社区药剂师患者中有 20%至 30%存在共同使用的情况。酒精和阿片类药物的共同使用是阿片类药物相关过量的一个重大风险因素。社区药房是解决美国阿片类药物流行的一个有价值但尚未充分利用的资源和场所,对于识别和干预与酒精和阿片类药物共同使用相关的风险具有未开发的潜力。本评论描述了“阿片类药物共同使用和酒精预防研究(COAPS)”,为减轻社区药房中酒精(风险和非风险使用)和阿片类药物共同使用带来的严重风险提供了一种创新且有前途的方法。COAPS 的目标 1 涉及改编现有的阿片类药物滥用干预措施,以针对酒精和阿片类药物共同使用进行目标治疗。COAPS 的目标 2 涉及在小规模试点随机对照试验(N=40)中测试改编后的干预措施,以检验干预措施与标准护理相比的可行性、可接受性和初步疗效。COAPS 的目标 3 涉及进行关键意见领袖访谈,以了解未来在社区药房环境中进行更大规模研究或提供服务的情况。

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